Krzysztof P. Rembacz

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Hexavalent chromium (VI) compounds are widely used in industry, while trivalent chromium (III) is used as a nutritional supplement. CrVI is generally considered more toxic and carcinogenic than its trivalent form and the toxicity of this metal is associated with free radical processes generating reactive oxygen species (ROS). The detailed mechanism of ROS(More)
This study investigated the role of 17beta-estradiol in chromium-generated oxidative stress in order to determine whether it has a detoxifying activity or increases the toxic effects of chromium compounds. Reduced glutathione (GSH) levels, membrane lipid peroxidation (levels of malondialdehyde -- MDA), glutathione peroxidase (GPx), and superoxide dismutase(More)
Cisplatin is the alkylating anticancer drug. These drugs show many side-effects including the damage of kidney. The nephrotoxicity of cisplatin is explained mainly by reactive oxygen species (ROS) generation. The increased level of lipids peroxidation was observed in patients treated with this drug. In the toxicity of cisplatin, are also involved reactive(More)
Streptomycetes are complex soil bacteria capable of producing aerial reproductive mycelium and secondary metabolites. We observed novel phenomena such as an extended life cycle including flotation and anaerobiosis using standing liquid cultures. This paper describes an improved method for isolating good quality RNA from standing liquid cultures of S.(More)
A series of novel sulfonamide isoxazolo[5,4-b]pyridines were synthesized. The substrates for their synthesis were 3-aminoisoxazolo[5,4-b]pyridine and selected aryl sulfonic chlorides, chlorosulfonic acid and selected amines. Reactions were carried out using the classical and microwave methods. Selected compounds were tested towards antibacterial and(More)
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