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OBJECTIVE To evaluate the efficacy and safety of AM-111, a c-Jun N-terminal Kinase (JNK) ligand, in patients with acute sensorineural hearing loss (ASNHL). STUDY DESIGN Prospective, double-blind, randomized, placebo-controlled study with follow-up visits on Days 3, 7, 30, and 90. SETTING Twenty-five European sites (academic tertiary referral centers,(More)
In order to test the frequency specificity of the efferent suppressive effect on otoacoustic emissions, changes in the 2f1-f2 distortion product otoacoustic emission (DPOAE) levels induced by contralateral stimuli of different spectra were measured in 10 normally hearing adults. Three types of contralateral stimuli were used: (i) a set of 6 pairs of pure(More)
1 The majority of moderate to severe sensorineural hearing loss individuals must rely on amplification of the acoustic signal to improve communication skills. This aim is generally accomplished with conventional air conduction hearing aids [1]. In some cases, hearing aid wearers report difficulties and limited adoption of hearing aids due to ear canal(More)
OBJECTIVE To evaluate the efficacy and safety of intratympanic AM-101 in patients with persistent acute inner ear tinnitus after acute acoustic trauma, idiopathic sudden sensorineural hearing loss (ISSNHL), or acute otitis media. STUDY DESIGN Prospective, double-blind, randomized, placebo-controlled study with follow-up visits on Days 7, 30, and 90. (More)
In this study, a new monitoring system is developed to measure cochlear blood flow (CBF) and electrocochleography (ECochG) during transient ischemic episodes of the cochlea. A newly designed otic probe was used for the simultaneous recordings of laser-Doppler CBF and ECochG directly from the round window (RW). The probe enabled the recording of high(More)
The goal of this study was to examine healthy young, mature, old and elderly using Computerized Dynamic Posturography (Smart EquiTest, Neurocom Int,), to collect their data and assess if balance differs significantly with age. Subjects were divided into four age groups: 20-30, 40-50, 60-69, 70-80 years. Their dynamic balance was tested using Sensory(More)
Distortion product otoacoustic emission (DPOAE) levels and latencies are accepted as a beneficial tool for investigating the micromechanics of the cochlea. Latencies for DPOAEs were examined in two groups of subjects: G1, consisting of 60 healthy young adults, aged 17-32 years, and G2 consisting of 74 miners, aged 19-35 years, exposed to mainly work-related(More)
OBJECTIVES The aim of this study was to observe the effects of mannitol, administered topically at the round window (RW), on cochlear blood flow (CBF) and distortion-product otoacoustic emission (DPOAE) after repeated episodes of cochlear ischemia. METHODS Ten young rabbits were used for this study. Reversible ischemic episodes within the cochlea were(More)
UNLABELLED The relationship between diabetes mellitus and hearing impairment has been studied for more than 100 years, and is still a matter of controversy. In our study hearing in diabetic patients was studied by tonal audiometry, brain stem auditory evoked responses and evoked otoacoustic emissions. The aim of this study was to evaluate the function of(More)
BACKGROUND Internal auditory artery (IAA) spasm is thought to be one of the causes of postoperative sensory hearing loss after attempted hearing preservation removal of an acoustic neuroma. The use of topical papaverine, a nonspecific vasodilator, to prevent vascular insufficiency to the inner ear and to improve hearing outcomes has been suggested but not(More)