Krzysztof F. Morawski

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OBJECTIVE To evaluate the efficacy and safety of AM-111, a c-Jun N-terminal Kinase (JNK) ligand, in patients with acute sensorineural hearing loss (ASNHL). STUDY DESIGN Prospective, double-blind, randomized, placebo-controlled study with follow-up visits on Days 3, 7, 30, and 90. SETTING Twenty-five European sites (academic tertiary referral centers,(More)
HYPOTHESIS Intraoperative monitoring by distortion-product otoacoustic emissions reflects the cochlear function changes in the real-time domain during removal of cerebellopontine angle tumors. BACKGROUND Cerebellopontine angle tumor surgery is associated with a significant risk of damaging internal auditory canal contents. Although monitoring facial nerve(More)
In order to test the frequency specificity of the efferent suppressive effect on otoacoustic emissions, changes in the 2f1-f2 distortion product otoacoustic emission (DPOAE) levels induced by contralateral stimuli of different spectra were measured in 10 normally hearing adults. Three types of contralateral stimuli were used: (i) a set of 6 pairs of pure(More)
The majority of moderate to severe sensorineural hearing loss individuals must rely on amplification of the acoustic signal to improve communication skills. This aim is generally accomplished with conventional air conduction hearing aids [1]. In some cases, hearing aid wearers report difficulties and limited adoption of hearing aids due to ear canal(More)
OBJECTIVE To investigate the use of transtympanic electrocochleography (TT-ECochG) analyzed on-line by a detector strategy software that made possible automatic extraction of TT-ECochG components intraoperatively in real-time domain. PATIENTS Fifteen patients with cerebellopontine angle tumor among 50 patients were included in this study. INTERVENTION(More)
In this study, a new monitoring system is developed to measure cochlear blood flow (CBF) and electrocochleography (ECochG) during transient ischemic episodes of the cochlea. A newly designed otic probe was used for the simultaneous recordings of laser-Doppler CBF and ECochG directly from the round window (RW). The probe enabled the recording of high(More)
OBJECTIVE Guidelines for appropriate management of vestibular schwannomas in NF2 patients are controversial. In this paper we reviewed our experience with patients with NF2 for the results of surgical treatment with particular reference to hearing and facial nerve preservation. METHODS We included in the study 30 patients (16 women and 14 men) with the(More)
OBJECTIVES The aim of this study was to observe the effects of mannitol, administered topically at the round window (RW), on cochlear blood flow (CBF) and distortion-product otoacoustic emission (DPOAE) after repeated episodes of cochlear ischemia. METHODS Ten young rabbits were used for this study. Reversible ischemic episodes within the cochlea were(More)
The goal of this study was to examine healthy young, mature, old and elderly using Computerized Dynamic Posturography (Smart EquiTest, Neurocom Int,), to collect their data and assess if balance differs significantly with age. Subjects were divided into four age groups: 20-30, 40-50, 60-69, 70-80 years. Their dynamic balance was tested using Sensory(More)
OBJECTIVE The purpose was to assess learning and rehabilitation effect and their influence on Sensory Organization Test results in young and elderly patients with peripheral, central and mixed vestibular pathology. MATERIAL AND METHODS 26 patients with different vestibular system deficits participated in this study. Rehabilitation was held five days a(More)