Krzysztof Banaszkiewicz

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BACKGROUND Huntington's disease (HD) is a rare triplet repeat (CAG) disorder. Advanced, multi-centre, multi-national research frameworks are needed to study simultaneously multiple complementary aspects of HD. This includes the natural history of HD, its management and the collection of clinical information and biosamples for research. METHODS We report(More)
Several candidate modifier genes which, in addition to the pathogenic CAG repeat expansion, influence the age at onset (AO) in Huntington disease (HD) have already been described. The aim of this study was to replicate association of variations in the N-methyl D-aspartate receptor subtype genes GRIN2A and GRIN2B in the "REGISTRY" cohort from the European(More)
The aim of this study was to identify determinants of functional disability, patient's quality of life (QoL) and caregivers' burden in Huntington's disease (HD). Eighty HD patients participated in the study. Motor and behavioral disturbances as well as cognitive impairment were assessed using motor, behavioral and cognitive parts of the Unified Huntington(More)
BACKGROUND AND PURPOSE Falls are a common and serious problem among Parkinson's disease (PD) patients. However, knowledge about the causes and risk factors of falls is limited. There have been a few attempts to classify the causes of falls. The classification suggested by Olanow seems to be the most comprehensive one. The aim of this study was to analyze(More)
BACKGROUND AND PURPOSE Intrinsic factors are the main cause of falls in Parkinson's disease (PD). The relation between different symptoms or type of PD and frequency of falls has been unclear so far. The aim of the study was to assess the frequency and causes of falls in postural instability and gait difficulty dominant PD (PIGD) and tremor dominant PD(More)
BACKGROUND AND PURPOSE Tremor accompanies some poly-neuropathies, but its prevalence and its clinical and electrophysiological manifestations are not well known. The aim of the study was to assess the occurrence and characteristics of hand tremor in patients with polyneuropathy of different origins, as well as relations between the occurrence of tremors and(More)
BACKGROUND AND PURPOSE There are several instrumental and clinical methods to assess hand tremor. The clinical methods, e.g. rating scales, have the advantage that they are available to most clinicians; however, they require experience, and are not as repeatable as instrumental methods. The study describes the use of a method based on a digitizing tablet(More)
BACKGROUND AND PURPOSE Bradykinesia, which is commonly defined as slowness of movements, is one of the cardinal signs of Parkinson's disease (PD) and parkinsonian syndromes. Simple clinical rating scales are used commonly to measure bradykinesia in routine clinical practice although this kind of assessment is biased. The aim of the study was to evaluate the(More)
BACKGROUND AND PURPOSE Huntington's disease (HD) is a neurodegenerative, progressive disorder of the central nervous system which causes significant gait and balance disturbances. This is a pilot study which aims to determine the effects of a physiotherapy programme with use of Proprioceptive Neuromuscular Facilitation (PNF) on gait and balance in HD(More)
AIM The aim of this study is to discuss diagnostic and therapeutic challenges in a patient with a mutation in the gene responsible for the development of Huntington's disease (HD) who presented schizophrenia-like psychotic symptoms. METHOD A case report. RESULTS A 35-year old man with genetically-confirmed HD who developed significant behavioural(More)