Krystian Kubica

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Experiments show significant effects of an electric field on lipid membrane, leading to a pore formation when a high intensity field is applied. The phenomenon of electroporation is preceded by the induction and expansion of defects, responsible for the pre-pore excitation. We examine the mechanism of the induction of the field-driven defects by Monte Carlo(More)
We present a novel approach to analysis of the gel-fluid transition of lipid membrane. The method is based on the Pink's model but in contrast to its standard version the dipole character of the lipid molecules polar part is considered. Moreover, less constrained movement of entire molecules is allowed. Such an approach includes into the model conditions(More)
Models of lipid bilayer were extended and dipole structure of polar head in lipid molecules was included. As a result a wavy structure, resembling experimentally observed 'ripple phase', was obtained. The discussion on significance of interactions between dipoles that constitute polar part of the model membrane is presented. Assumptions of the model are(More)
Cholesterol is a vital structural and functional molecule in the human body that is only slightly soluble in water and therefore does not easily travels by itself in the bloodstream. To enable cholesterol's targeted delivery to cells and tissues, it is encapsulated by different fractions of lipoproteins, complex particles containing both proteins and(More)
Pathogenic T. pallidum cells possess and extracellular layer when observed in vivo and in vitro after exposure to ruthenium-red. The extracellular layer is partially removed from a pre-fixed cell by repeated washing in vitro. Non-pathogenic treponemes examined in this study do not possess an extracellular layer. It is hoped that the data presented herein(More)
Membrane electroporation seems to be a useful method for delivery of biological active compounds into the cell. Although it is known that this phenomenon is sensitive to the electric field intensity, duration of the electric pulse and its shape, it is not fully understood. In some theoretical descriptions it is postulated that a hydrophobic pore appears at(More)
Cholesterol plays a vital role in human body. Its unbalanced homeostasis, however, leads to health related problems. The elevated blood cholesterol levels are now considered a classic coronary risk factor and are suspected to lead to coronary artery diseases, causing 2.6 millions of deaths each year. Here, we develop a two-compartment mathematical model to(More)
Ripple phase modelling was achievable by taking into consideration the dipole structure of the polar heads of model membrane molecules. Computer simulations enabled the selective analysis of a model membrane. Considering only the hydrophobic part of the lipid membrane, the gel-fluid transition stage can be obtained in such a simulation. Assuming an(More)