Kritina L. Holden

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Two experiments examined selecting text using a movement sequence of pointing and dragging. Experiment 1 showed that, in the Point-Drag sequence, the pointing time was related to the pointing distance but not to the width of the text to be selected; in contrast, pointing time was related to both the pointing distance and the width of the text in the(More)
DNA-carcinogen adducts offer a potential dosimeter for environmental genotoxicants reaching the exposed individual. Because the target tissues for many chemical carcinogens are not readily accessible for monitoring adducts in humans, peripheral blood lymphocytes (PBLs) have served as surrogate sources of exposed DNA. Both benzo[a]pyrene (BaP) and(More)
Discriminant function and polynomial regression methods were used to define a mental age function from scale score profile patterns found in the WAIS manual. Values on the mental age function then were calculated from WAIS scale score profiles for 164 alcoholics in the age range 35 to 74. Validity of the mental age function was evident in clear(More)
The paper challenges the notion that any Fitts' Law model can be applied generally to human-computer interaction, and proposes instead that applying Fitts' Law requires knowledge of the users' sequence of movements, direction of movement, and typical movement amplitudes as well as target sizes. Two experiments examined a text selection task with sequences(More)
A 6-week double-blind comparison of the therapeutic efficacy of alprazolam and imipramine in 90 depressed psychiatric outpatients revealed a significantly superior response to alprazolam in the first 2 weeks of treatment as measured by total scores on the Hamilton Rating Scale for Depression and the Brief Psychiatric Rating Scale. Further analyses revealed(More)
Common DNA isolation methods rely upon protein denaturation by organic solvents such as phenol and chloroform. These solvents pose some risk to the user and require special disposal procedures. We previously reported a method for isolating DNA from peripheral blood lymphocytes by precipitation with spermine (1). This procedure proved less effective with(More)
Benzo[b]fluoranthene (B[b]F) was administered (100 mg/kg by i.p. injection) to male Sprague--Dawley rats. Lungs, livers and peripheral blood lymphocytes (PBLs) were harvested 1, 3, 5, 7, 14, 28 and 56 days after treatment. Several DNA adducts were observed in each tissue, with maximal levels occurring at approximately 7 days after treatment. Lung DNA(More)
BACKGROUND The ability to appreciate humour is essential to successful human interactions. In this study, we hypothesized that individuals with schizophrenia would have diminished ability to recognize and appreciate humour. The relationship between humour experience and clinical symptoms, cognitive and social functioning was examined. METHOD Thirty(More)
Computer systems offering windowing environments have been readily embraced by the computer user community. These capabilities have become so popular in recent years, that even the more traditional command-line systems such as IBM PCs are offering windowing environments. The question arises as to whether or not a windowing environment is appropriate for any(More)