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Because iron toxicity and deficiency are equally life threatening, maintaining intracellular iron levels within a narrow optimal range is critical for nearly all known organisms. However, regulatory mechanisms that establish homeostasis are not well understood in organisms that dwell in environments at the extremes of pH, temperature, and salinity. Under(More)
Organisms across all three domains of life use gene regulatory networks (GRNs) to integrate varied stimuli into coherent transcriptional responses to environmental pressures. However, inferring GRN topology and regulatory causality remains a central challenge in systems biology. Previous work characterized TrmB as a global metabolic transcription factor in(More)
Previous work has shown that the hypersaline-adapted archaeon, Halobacterium salinarum NRC-1, is highly resistant to oxidative stress caused by exposure to hydrogen peroxide, UV, and gamma radiation. Dynamic alteration of the gene regulatory network (GRN) has been implicated in such resistance. However, the molecular functions of transcription regulatory(More)
Networks of interacting transcription factors are central to the regulation of cellular responses to abiotic stress. Although the architecture of many such networks has been mapped, their dynamic function remains unclear. Here we address this challenge in archaea, microorganisms possessing transcription factors that resemble those of both eukaryotes and(More)
BACKGROUND AND OBJECTIVE Regenerative medicine involves the bioengineering of a functional tissue or organ by seeding living cells on a biodegradable scaffold cultured in a bioreactor. A major barrier to creating functional tissues, however, has been the inability to monitor the dynamic and complex process of scaffold maturation in real time, making control(More)
Training on micro- and nano- computed tomography (CT) scanners has been traditionally conducted via extensive practice on the instrument. This entails presence of an instructor to guide through the training procedure, until reasonable experience is attained. Modern tomographic instruments being expensive to maintain, the operational costs escalates with(More)
The demand for an accurate biometric system that provides reliable identification and verification of an individual has increased over the years. A biometric system that provides reliable and accurate identification of an individual is an iris recognition system. Iris recognition systems capture an image of an individual's eye; the iris in the image is then(More)
In late 1950s, two mathematicians discovered a network with complex topology by random graph theory. Complex networks have received great attention in past few decades. Many studies have been done on complex networks and many are still in progress. Complex Networks are the networks which can be seen in real as well as in technological systems. They have(More)
With time E-Learning is flourishing widespread and exponentially. Enabling E-Learning in organisation or practising at home not only allows learners from all over globe to advance their learning but also reduce organisational time and cost to make a mass learn through training session. In my paper I discuss about a learning platform where authenticated(More)
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