Kriti Sen Sharma

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Organisms across all three domains of life use gene regulatory networks (GRNs) to integrate varied stimuli into coherent transcriptional responses to environmental pressures. However, inferring GRN topology and regulatory causality remains a central challenge in systems biology. Previous work characterized TrmB as a global metabolic transcription factor in(More)
BACKGROUND AND OBJECTIVE Regenerative medicine involves the bioengineering of a functional tissue or organ by seeding living cells on a biodegradable scaffold cultured in a bioreactor. A major barrier to creating functional tissues, however, has been the inability to monitor the dynamic and complex process of scaffold maturation in real time, making control(More)
Because iron toxicity and deficiency are equally life threatening, maintaining intracellular iron levels within a narrow optimal range is critical for nearly all known organisms. However, regulatory mechanisms that establish homeostasis are not well understood in organisms that dwell in environments at the extremes of pH, temperature, and salinity. Under(More)
Previous work has shown that the hypersaline-adapted archaeon, Halobacterium salinarum NRC-1, is highly resistant to oxidative stress caused by exposure to hydrogen peroxide, UV, and gamma radiation. Dynamic alteration of the gene regulatory network (GRN) has been implicated in such resistance. However, the molecular functions of transcription regulatory(More)
1 Partnership for Child Development, Imperial College London, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom, 2 Deworm theWorld, Washington, D.C., United States of America, 3 London Centre for Neglected Tropical Disease Research, Imperial College London, School of Public Health, Faculty of Medicine, London,(More)
Networks of interacting transcription factors are central to the regulation of cellular responses to abiotic stress. Although the architecture of many such networks has been mapped, their dynamic function remains unclear. Here we address this challenge in archaea, microorganisms possessing transcription factors that resemble those of both eukaryotes and(More)
Training on micro- and nano- computed tomography (CT) scanners has been traditionally conducted via extensive practice on the instrument. This entails presence of an instructor to guide through the training procedure, until reasonable experience is attained. Modern tomographic instruments being expensive to maintain, the operational costs escalates with(More)
The demand for an accurate biometric system that provides reliable identification and verification of an individual has increased over the years. A biometric system that provides reliable and accurate identification of an individual is an iris recognition system. Iris recognition systems capture an image of an individual's eye; the iris in the image is then(More)
With time E-Learning is flourishing widespread and exponentially. Enabling E-Learning in organisation or practising at home not only allows learners from all over globe to advance their learning but also reduce organisational time and cost to make a mass learn through training session. In my paper I discuss about a learning platform where authenticated(More)
India is one of the biggest makers of blossoms, organic products, and so on. In any case, the monetary commitment of agriculture to India’s. Total national output (GDP) is consistently declining. Hence distinctive issues are rising in the parts of agriculture generation and promoting. These issues have hence prompted new techniques in the rural examination.(More)