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Because iron toxicity and deficiency are equally life threatening, maintaining intracellular iron levels within a narrow optimal range is critical for nearly all known organisms. However, regulatory mechanisms that establish homeostasis are not well understood in organisms that dwell in environments at the extremes of pH, temperature, and salinity. Under(More)
Organisms across all three domains of life use gene regulatory networks (GRNs) to integrate varied stimuli into coherent transcriptional responses to environmental pressures. However, inferring GRN topology and regulatory causality remains a central challenge in systems biology. Previous work characterized TrmB as a global metabolic transcription factor in(More)
Previous work has shown that the hypersaline-adapted archaeon, Halobacterium salinarum NRC-1, is highly resistant to oxidative stress caused by exposure to hydrogen peroxide, UV, and gamma radiation. Dynamic alteration of the gene regulatory network (GRN) has been implicated in such resistance. However, the molecular functions of transcription regulatory(More)
Networks of interacting transcription factors are central to the regulation of cellular responses to abiotic stress. Although the architecture of many such networks has been mapped, their dynamic function remains unclear. Here we address this challenge in archaea, microorganisms possessing transcription factors that resemble those of both eukaryotes and(More)
Micro computed tomography (micro-CT) is a widely-used imaging technique. A challenge of micro-CT is to quantitatively reconstruct a sample larger than the field-of-view (FOV) of the detector. This scenario is characterized by truncated projections and associated image artifacts. However, for such truncated scans, a low resolution scout scan with an(More)
In late 1950s, two mathematicians discovered a network with complex topology by random graph theory. Complex networks have received great attention in past few decades. Many studies have been done on complex networks and many are still in progress. Complex Networks are the networks which can be seen in real as well as in technological systems. They have(More)
This article outlines the use of the multidisciplinary approach to mood disorders in the Short Stay Psychiatric Unit (SSPU) in Mater Dei Hospital, Msida, Malta. An audit was carried out on all patients whose first admission to SSPU was in 2008 and who were diagnosed with having a mood disorder. The aim was to see whether the use of a multidisciplinary(More)
This article outlines a case of anorexia nervosa within the context of its multifactorial etiology and complex neurobiology. Additionally, it also highlights that in this case there were several co-morbid personality traits and other psychiatric co-morbidites such as OCD and bipolar disorder.
With time E-Learning is flourishing widespread and exponentially. Enabling E-Learning in organisation or practising at home not only allows learners from all over globe to advance their learning but also reduce organisational time and cost to make a mass learn through training session. In my paper I discuss about a learning platform where authenticated(More)