Kriti Priya Gupta

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The predominant characteristics of multidrug resistant (MDR) cancer cells are broad spectrum resistance to chemotherapeutic agents and a pronounced defect in intracellular accumulation of the drugs, in association with overexpression of the drug efflux pump P-glycoprotein. Protein kinase C (PKC) phosphorylates the linker region of P-glycoprotein. Evidence(More)
We investigated the effects that phorbol ester and diacylglycerol protein kinase C (PKC) activators had on the chemosensitivity of the human colon cancer cell line KM12L4a to Adriamycin (ADR), vincristine (VCR), and vinblastine (VLB) and on the intracellular accumulation of those drugs. Exposure of the cells to the PKC activator phorbol-12,13-dibutyrate(More)
Murine fibrosarcoma UV-2237MM cells were implanted into different organs of syngeneic C3H/HeN mice. The resultant tumors were treated by i.v. administration of Adriamycin (ADR). Despite the high sensitivity of the fibrosarcoma cells to ADR in vitro, the established tumors growing in vivo exhibited marked differences in their responses to ADR. Tumors growing(More)
The high affinity receptor of phorbol-ester and related tumor promoters is the isozyme family protein kinase C (PKC). Activation of PKC by the phorbol esters is a pivotal event in phorbol ester-mediated tumor promotion. PKC activation is also implicated in tumor promotion of colonic epithelial cells by endogenous and dietary factors such as bile acids, free(More)
Recent studies have implicated protein kinase C (PKC) activation in drug resistance in vitro. PKC can be activated directly by phorbol-ester tumor promoters as well as by the bile acid deoxycholate. In this report, we demonstrate that deoxycholate, at concentrations that are chronically present in the lumen of the colon in vivo, mimicked phorbol-ester tumor(More)
Phorbol ester protein kinase C (PKC) activators and PKC isozyme over-expression have been shown to significantly reduce intracellular accumulation of chemotherapeutic drugs, in association with the induction of multidrug resistance (MDR) in drug-sensitive cancer cells and enhancement of drug resistance in MDR cancer cells. These observations constitute(More)
a large leech which he had pulled out of the left nostril. He said, as he was lying "down he felt something creeping in his nose, and as soon as the leech had protruded itself, he pulled it out with his fingers. He also affirmed that there was still another in the same nostril, for he had felt something creeping within his nose after the exit of the first(More)
By Surgn.-Lt.-Coi,. K. P. Gupta, m.b., f.u.c.s., Civil Surgn.t BacTtergunge, Offg. Civil Surgeon, Ilughli. From 1st July to 31st December 1892, there were 8G post-mortem examinations of dead bodies sent up by the police. In the first half of the same year the number exceeded a hundred, but in the latter half it has fallen short. This decrease is to be(More)
In 1892-93, I gave a resume of the medicolegal work in this district with details of some gunshot wounds. The number of police postmortems in 1892 was 206 and in 1893 211. Coining to 1894 the number seems to have fallen off to 174. Out of this number, 52 were suicide b}^ hanging, viz., 37 females and 15 males. The ages of the female suicides varied from 11(More)