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Quantification of radiotracer uptake in breast lesions can provide valuable information to physicians in deciding patient care or determining treatment efficacy. Physical processes (e.g., scatter, attenuation), detector/collimator characteristics, sampling and acquisition trajectories, and reconstruction artifacts contribute to an incorrect measurement of(More)
An observer-based contrast-detail study is performed in an effort to evaluate the limits of object detectability using a dedicated CZT-based breast SPECT imaging system under various imaging conditions. A custom geometric contrast-resolution phantom was developed that can be used for both positive ('hot') and negative contrasts ('cold'). The 3 cm long(More)
Attenuation correction is necessary for SPECT quantification. There are a variety of methods to create attenuation maps. For dedicated breast SPECT imaging, it is unclear if either SPECT- or CT-based attenuation map would provide the most accurate quantification and whether or not segmenting the different tissue types will have an effect on the(More)
A small field of view, high resolution gamma camera has been integrated into a dedicated breast, single photon emission computed tomography (SPECT) device. The detector can be flexibly positioned relative to the breast and image beyond the chest wall, allowing the system to capture direct views of the heart and liver. The incomplete sampling of these organs(More)
A pilot study is underway to quantify in vivo the uptake and distribution of Tc-99m Sestamibi in subjects without previous history of breast cancer using a dedicated SPECT-CT breast imaging system. Subjects undergoing diagnostic parathyroid imaging studies were consented and imaged as part of this IRB-approved breast imaging study. For each of the seven(More)
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