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- Kristopher S. Silver, David M. Soderlund
- Neurotoxicology
- 2005
Insecticidal pyrazolines inhibit voltage-sensitive sodium channels of both insect and mammalian neurons in a voltage-dependent manner. Studies on the effects of pyrazoline insecticides on mammalian… (More)
- Cynthia L Goodman, David Stanley, Joseph A. Ringbauer, Richard W. Beeman, Kristopher S. Silver, Yoonseong Park
- In Vitro Cellular & Developmental Biology…
- 2012
The red flour beetle, Tribolium castaneum, is a model organism for agricultural and medical research and its complete genome is sequenced. We established a continuously replicating T. castaneum cell… (More)
- Ke Xiu Dong, Yuzhe Du, +5 authors Boris S. Zhorov
- Insect biochemistry and molecular biology
- 2014
Voltage-gated sodium channels are essential for the initiation and propagation of the action potential in neurons and other excitable cells. Because of their critical roles in electrical signaling,… (More)
- Kristopher S. Silver, Weizhong Song, Yoshiko Nomura, Vincent L. Salgado, Ke Dong
- Pesticide biochemistry and physiology
- 2010
Sodium channel blocker insecticides (SCBIs) are a relatively new class of insecticides, with a mechanism of action different from those of other classes of insecticides that target voltage-gated… (More)
- Weizhong Song, Kristopher S. Silver, Yuzhe Du, Zhiqi Liu, Ke Dong
- Insect biochemistry and molecular biology
- 2011
A new class of sodium channel blocker insecticides (SCBIs), which include indoxacarb, its active metabolite, DCJW, and metaflumizone, preferably block inactivated states of both insect and mammalian… (More)
- Richard T von Stein, Kristopher S. Silver, David M. Soderlund
- Pesticide biochemistry and physiology
- 2013
Sodium channel inhibitor (SCI) insecticides were discovered almost four decades ago but have only recently yielded important commercial products (eg., indoxacarb and metaflumizone). SCI insecticides… (More)
- Kristopher S. Silver, Hongbo Jiang, Jinping Fu, Thomas W. Phillips, Richard W. Beeman, Yoonseong Park
- Scientific reports
- 2014
The red flour beetle, Tribolium castaneum, is an agriculturally important insect pest that has been widely used as a model organism. Recently, an adherent cell line (BCIRL-TcA-CLG1 or TcA) was… (More)
- Kristopher S. Silver, David M. Soderlund
- Neurotoxicology
- 2007
Pyrazoline-type insecticides (PTIs) selectively block sodium channels at membrane potentials that promote slow sodium channel inactivation and are proposed to interact with a site that overlaps the… (More)
- Kristopher S. Silver, Ludovic Leloup, Lisa C. Freeman, Alan Wells, James D Lillich
- The international journal of biochemistry & cell…
- 2010
Non-steroidal anti-inflammatory drugs (NSAIDs) are used frequently worldwide for the alleviation of pain despite their capacity to cause adverse gastrointestinal (GI) side effects. GI toxicity, once… (More)
- Kristopher S. Silver, David M. Soderlund
- Toxicology and applied pharmacology
- 2006
Pyrazoline-type insecticides are potent inhibitors of insect and mammalian voltage-sensitive sodium channels. In mammals, there are nine sodium channel alpha subunit isoforms that have unique… (More)