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Idiosyncratic Mòjiāng virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses
TLDR
The inability of MojV-G to interact with known paramyxoviral receptors in vitro is confirmed, indicating an independence from well-characterized ephrinB2/B3, sialic acid and CD150-mediated entry pathways.
Quantifying absolute neutralization titers against SARS-CoV-2 by a standardized virus neutralization assay allows for cross-cohort comparisons of COVID-19 sera
TLDR
A standardized VNA using VSVdeltaG based CoV-2-S pseudotyped particles (CoV2pp) that can be robustly produced at scale and showed a strong positive correlation with CoV1-S ELISA and live virus neutralizations in a validated set of patient sera is developed.
A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus
TLDR
The structural and functional insights presented uncover diversity within the known henipavirus receptor repertoire and suggest that only modest structural changes may be required to modulate receptor specificities within this group of lethal human pathogens.
A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus
TLDR
CedV possesses a unique cellular entry receptor repertoire which, in addition to functional utilization of the common HNV receptor, includes the hitherto uncharacterized interaction with ephrin-B1, andCrystal structures reveal a conserved recognition mode between diverse HNV-G proteins and their distinct Ephrin receptors and identify a region of molecular specificity within CedV-G that is a key determinant of ephrine selectivity.
Viral Determinants of miR-122-Independent Hepatitis C Virus Replication
TLDR
This work knocked out miR-122 using clustered regularly interspaced short palindromic repeat (CRISPR) technology and adapted virus to replicate in the presence of noncognate miR -122 RNAs and identified viral mutations that allow HCV replication in the complete absence of this miRNA.
Naturally Arising Strains of Polyomaviruses with Severely Attenuated MicroRNA Expression
TLDR
This study informs how miRNA genes evolve/devolve in viruses and suggests that miRNA function is exquisitely dependent not only on viral genomic context but also on the cellular and host environment.
Differential Features of Fusion Activation within the Paramyxoviridae
TLDR
A better understanding of conserved and distinct features that govern the entry of protein-using versus SA-using PMVs will inform the rational design of broader spectrum therapeutics that impede this process.
Cross-Reactive and Cross-Neutralizing Activity of Human Mumps Antibodies Against a Novel Mumps Virus From Bats
TLDR
The data suggest that persons who have neutralizing antibodies against MuV might be protected from infection by BMV and cross-neutralizing activity against rMuVJL5-F/HNBMV.
Quantifying Absolute Neutralization Titers against SARS-CoV-2 by a Standardized Virus Neutralization Assay Allows for Cross-Cohort Comparisons of COVID-19 Sera
TLDR
A standardized replication-defective pseudotyped particle system that mimics the entry of live SARS-CoV-2 and shows a strong positive correlation with CoV2-S enzyme-linked immunosorbent assay results and live-virus neutralizations in confirmed convalescent-patient sera is developed.
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