Kristine M. Williams

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Enzymes catalysing the methylation of the 5-position of cytosine (mC) have essential roles in regulating gene expression and maintaining cellular identity. Recently, TET1 was found to hydroxylate the methyl group of mC, converting it to 5-hydroxymethyl cytosine (hmC). Here we show that TET1 binds throughout the genome of embryonic stem cells, with the(More)
The JmjC domain-containing protein JMJD3/KDM6B catalyses the demethylation of H3K27me3 and H3K27me2. JMJD3 appears to be highly regulated at the transcriptional level and is upregulated in response to diverse stimuli such as differentiation inducers and stress signals. Accordingly, JMJD3 has been linked to the regulation of different biological processes(More)
The contents of this report reflect the views of the authors who are responsible for the facts and the accuracy of the information presented herein. The report does not constitute a standard, specification, or regulation. Local governments should seek professional planning and legal assistance in developing a corridor management program. Coordination with(More)
OBJECTIVES The objective of this handbook is to assist planners and engineers in developing a public involvement strategy for controversial access management issues. The strategies are designed to facilitate open communication with affected parties and to assure adequate public involvement at key steps in the decision process. The emphasis is on median(More)
Acknowledgements Appreciation is expressed to the following individuals for their helpful comments: Transportation projects can have major social and economic effects—both positive and negative. Analysis of community impacts provides insight into ways projects can be improved or redefined to reduce adverse impacts and increase overall project benefits.(More)
ii PREFACE Concurrency is a growth management concept intended to ensure that the necessary public facilities and services are available concurrent with the impacts of development. To carry out transportation concurrency, local governments must define what constitutes an adequate level of service (LOS) and measure whether the service needs of a new(More)
The opinions, findings, and conclusions expressed in this publication are those of the authors and not necessarily those of the State of Florida Department of Transportation. Despite the increasing importance of comprehensive corridor management at the state and local government level, questions remain regarding effective methods for developing and(More)