Kristine M. Miller

Learn More
BACKGROUND The 2-L polyethylene glycol (PEG) lavage solutions provide efficacy similar to that of standard 4-L PEG formulations in spite of the reduced volume. The comparative efficacy and tolerability of two formulations of 2-L PEG solution remain unknown. AIMS To assess the efficacy, safety and tolerability of PEG + Bis compared with PEG + Asc, and to(More)
Three adult, female chickens, previously trained to detect pure tones using a positive reinforcement paradigm, were exposed to pure tones at 525 Hz at 120-dB sound-pressure level for 48 h. Immediately after exposure, pure-tone thresholds were elevated between 10 and 56 dB compared to pre-exposure values. The configuration of the initial hearing loss was(More)
High doses of aminoglycoside antibiotics cause massive damage to the avian basilar papilla. The resulting functional loss could conceivably arise from the reduction in the DC endocochlear potential (EP) due to impairment of the tegmentum vasculosum (TV) or to shunting of current through the damaged sensory epithelium. To test this hypothesis, the EP was(More)
Distortion product otoacoustic emissions (DPOAEs) were measured in chickens before and after exposure to a 525-Hz pure tone (120 dB SPL, 48 h). The exposure caused extensive hair cell loss and destroyed the tectorial membrane along the abneural edge of the basilar papilla in the low-to-mid-frequency region of the cochlea. Although the lesion was restricted,(More)
BACKGROUND Many individuals with gastroduodenal ulcers require on-going, non-steroidal anti-inflammatory drug (NSAID) or anti-platelet therapy. AIMS To evaluate the effects of these agents on gastroduodenal mucosal healing. METHODS Helicobacter pylori-negative volunteers were randomized to receive naproxen, celecoxib, aspirin, clopidogrel or placebo.(More)
BACKGROUND All colon polyps removed during colonoscopy should be recovered and submitted for histopathologic analysis. Published information is scant regarding techniques and devices for retrieval of polyps after polypectomy. The Roth Retrieval Net is a novel device that has been used to retrieve foreign bodies from the GI tract, but its use as a polyp(More)
The organization of neurons and the maintenance of that arrangement are critical to brain function. Failure of these processes in humans can lead to severe birth defects, mental retardation, and epilepsy. Several kinesins have been shown to play important roles in cell migration in vertebrate systems, but few upstream and downstream pathway members have(More)
BACKGROUND The basis for individual variation in gastroduodenal vulnerability to NSAIDs is not well understood. AIM To assess whether a gene expression signature is associated with susceptibility to gastroduodenal ulcerations. METHODS Twenty-five Helicobacter pylori negative adults were treated for 7 days with naproxen 500 mg b.d. Subjects underwent(More)