Kristine Lemke

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INTRODUCTION Nonoperative treatment of stage III non-small cell lung cancer has evolved over the past 30 years. The current approach in the Unites States most often includes concurrent chemoradiotherapy. METHODS We have used live, case-based research events to document prescribing plans among American medical oncologists for first-line therapy in patients(More)
There have been suggestions that analgesics be used by fish researchers. But in the absence of dose-response data for morphine, this suggestion seems imprudent. The purpose of the present study was to develop a dose-response relationship in fish using six doses of morphine. The response (movement of the fins or tail) to a noxious stimulus (electrical shock(More)
In the design of enzyme-based sensors, the measuring characteristics are mostly obtained by the trial-and-error method. An alternative is provided by mathematical simulation of the behaviour of the sensors. For this, a mathematical model was outlined which is described by two coubled inhomogeneous partial differential equations for each layer of the(More)
BACKGROUND AND PURPOSE Studying the effects of toxic and infective compounds on the respiratory system requires a reliable method for delivering inoculum into the distal region of the lung. Although transoral intratracheal inoculation methods have been well documented for adult rats, to the authors' knowledge, a reliable method has not been validated for(More)
Compact catalytic platinum-binder glucose sensors were developed, provided for the artificial beta-cell. These consist of three electrodes: the working electrode, a 0.5 mm diameter glass-sheathed platinum wire, covered with a mixture of platinum black and binder (PMMA, PVC) at the face, the reference electrode and the rejuvenating or counter electrode.(More)
Measurements with differential pulse voltammetry were carried out using an electrocatalytic glucose sensor based on a three-electrode system with a smooth platinum working electrode in a flow-through-type arrangement. The geometric area of the working electrode was 0.5 mm2. The influence of environmental conditions (temperature, pH, pCO2, pO2) was tested(More)
In the first part of the paper a mathematical model of the enzyme-substrate electrode with a pO2 basic sensor was outlined. This model is used to simulate the dependencies of the measuring characteristics (calibration curve, measuring range, sensitivity, response time) on the design parameters (geometric arrangement, membrane properties, enzyme kinetic(More)
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