Kristina Wanieck

Learn More
hBRCA1 and hBARD1 are tumor suppressor proteins that are involved as heterodimer via ubiquitinylation in many cellular processes, such as DNA repair. Loss of BRCA1 or BARD1 results in early embryonic lethality and chromosomal instability. The Arabidopsis genome carries a BRCA1 homologue, and we were able to identify a BARD1 homologue. AtBRCA1 and the(More)
BRCA1 is a well-known tumor suppressor protein in mammals, involved in multiple cellular processes such as DNA repair, chromosome segregation and chromatin remodeling. Interestingly, homologs of BRCA1 and several of its complex partners are also found in plants. As the respective mutants are viable, in contrast to mammalian mutants, detailed analyses of(More)
Abstract In the plant genome a row of homologs of human genes can be found that, if mutated, are correlated with a high incidence of cancer in humans. Here we describe our recent results on homologs of the breast cancer genes BRCA1/BARD1 and RecQ helicase homologs in the model plant Arabidopsis thaliana. HsBRCA1 and HsBARD1 are tumor suppressor proteins(More)
Biomimetics applies principles and strategies abstracted from biological systems to engineering and technological design. With a huge potential for innovation, biomimetics could evolve into a key process in businesses. Yet challenges remain within the process of biomimetics, especially from the perspective of potential users. We work to clarify the(More)
  • 1