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The prefrontal and temporal networks subserving object working memory tasks in adults have been reported as immature in young children; yet children are adequately capable of performing such tasks. We investigated the basis of this apparent contradiction using a complex object working memory task, a Categorical n-back (CN-BT). We examined whether the neural(More)
Event-related potentials (ERPs) and behavioral responses were recorded from autistic and normal subjects under two focused selective attention conditions. In each condition, subjects were presented with an identical stimulus paradigm--a random sequence of 50 msec sounds and flashes occurring at interstimulus intervals ranging between 0.5 and 1.5 sec. The(More)
A developmental chronometry hypothesis of early brain damage is suggested in which regions of the brain with a protracted course of postnatal development will be more vulnerable than earlier maturing areas to deleterious effects of early insult and, therefore, may become common sites of abnormality across many disorders originating in early childhood.(More)
BACKGROUND Following brain insult in early childhood, the later maturing neocerebellum and frontal lobes frequently show abnormalities. OBJECTIVE To investigate the morphologic characteristics and function of a proposed cerebellar-frontal subsystem in children treated for acute lymphoblastic leukemia (ALL) with intrathecal methotrexate using quantitative(More)
BACKGROUND Neurodevelopmental evidence of the cerebellum's protracted course of postnatal development suggests that it is particularly sensitive to early toxic insult from cancer therapy. If this is the case, one would expect that there is a relationship between the pattern of neuropsychological and magnetic resonance imaging deficits and that both may(More)
Event-related potentials (ERPs) and performance correlates of inhibition of responses to no-go stimuli were investigated in 6-12-year-old children and young adults. The percent of correct responses to go stimuli was high and similar in both groups; the percent of false alarm errors to no-go was significantly higher in children. Effective inhibition of(More)
Assessed survivors of childhood lymphoblastic leukemia (ALL) treated with intrathecal chemotherapy, using the Wide Range Assessment of Memory and Learning (WRAML), compared to controls without cancer, matched as closely as possible in age, SES, and gender. Mild, but consistent, deficits were found in both visual-spatial and verbal single-trial memory tasks.(More)
To investigate the hypothesis of anterior brain involvement in alcoholism, nonfamilial short-term drinkers (STD) and long-term drinkers (LTD) were assessed using neuropsychological tests commonly related to frontal lobe functions. Both STDs and LTDs were similarly impaired on measures of visually mediated concept formation and flexibility of thinking.(More)
The behavior and event-related potentials (ERPs) of high functioning subjects with autism (Autism group) were contrasted with the results of normal controls (Control group) during a focused visual attention, a focused auditory attention and a visual/auditory divided attention task. Detecting targets by the Autism group in the cross-modal divided attention(More)
This study was designed to replicate and extend earlier findings. Evoked potentials (EP) were recorded, using a task of varying complexity involving shape discrimination, with matched groups of obsessional and normal subjects. Results confirmed previous findings that obsessional patients are characterized by reduced amplitudes and decreased latencies of(More)