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OBJECTIVE The purpose of this article is to review the pharmacokinetic and pharmacodynamic properties of gadoxetate disodium (Gd-EOB-DTPA), to describe a workflow-optimized pulse sequence protocol, and to illustrate the imaging appearance of focal lesions in the noncirrhotic liver. CONCLUSION Gd-EOB-DTPA allows a comprehensive evaluation of the liver with(More)
BACKGROUND The two-stage liver resection combining in situ liver transection with portal vein ligation, also referred to as ALPPS (Associating Liver Partition and Portal vein ligation for Staged hepatectomy), has been described as a promising method to increase the resectability of liver tumors. However, one of the most important issues regarding the safety(More)
RATIONALE AND OBJECTIVES To assess the enhancement pattern of focal confluent fibrosis (FCF) on contrast-enhanced hepatic magnetic resonance imaging (MRI) using hepatocyte-specific (Gd-EOB-DTPA) and extracellular (ECA) gadolinium-based contrast agents in patients with primary sclerosing cholangitis (PSC). MATERIALS AND METHODS After institutional review(More)
OBJECTIVE The purpose of this study was to determine transit times for excretion of Gd-EOB-DTPA into different segments of the hepatobiliary system in patients with normal liver function. METHODS This retrospective study was IRB approved with a waiver of consent granted. 61 patients (39 female, 22 male, mean age 52.5 years) with normal liver and renal(More)
Lung cancer is the most common cancer worldwide. Early detection might reduce morbidity. In this study we evaluate a microCT imaging algorithm to assess in-vivo tumour load and quantification of tumour growth in a transgenic disease model of lung adenocarcinomas. MicroCT was carried out with n=10 SPC-raf transgenic mice without gating in spontaneously(More)
To the editor To the editor To the editor To the editor To the editor Standard treatment of autoimmune hepatitis (AIH) includes steroids such as predniso(lo)ne based upon study data established decades ago. 1,2 Pilot studies indicate that budesonide may represent an alternative treatment option. 3 Recently, this was confirmed in non-cirrhotic AIH patients(More)
The Amplatzer Vascular Plug (AVP) is a device originally intended for arterial and venous embolization in peripheral vessels. From December 2004 to March 2007 we implanted a total of 8 AVPs in the portal venous system in our institution for preoperative portal vein embolization in 4 patients (55-71 years) prior to right hemihepatectomy. AVP implantation was(More)
PURPOSE To test the null hypothesis that there is no quantitative or qualitative difference between respiratory-triggered three-dimensional (3D) T2-weighted magnetic resonance (MR) cholangiography performed before or after administration of gadoxetate disodium. MATERIALS AND METHODS For this retrospective HIPAA-compliant dual-center study, institutional(More)
PURPOSE To assess hepatobiliary excretion of gadoxetate disodium in patients with primary sclerosing cholangitis (PSC) over time and to determine a possible correlation with severity of the disease. MATERIALS AND METHODS A total of 111 patients (36 females, 75 males, mean age 41.5 yr) with confirmed diagnosis of PSC who underwent gadoxetate disodium(More)