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Cytokine profile in PFAPA syndrome suggests continuous inflammation and reduced anti-inflammatory response.
PFAPA syndrome is characterized by periodic episodes of high fever, aphthous stomatitis, pharyngitis, and/or cervical adenitis. It is of unknown etiology and manifests usually before 5 years of age.… Expand
Colchicine Use in Children and Adolescents With Familial Mediterranean Fever: Literature Review and Consensus Statement
The daily application of colchicine is the standard therapy for prophylaxis of attacks and amyloid deposition in familial Mediterranean fever. However, because of many issues (eg, dosage, time of… Expand
Antiviral efficacy, tolerability and pharmacokinetics of efavirenz in an unselected cohort of HIV-infected children.
- U. Wintergerst, F. Hoffmann, +4 authors D. Burger
- The Journal of antimicrobial chemotherapy
- 1 June 2008
OBJECTIVES To obtain data on the pharmacokinetics of efavirenz in children in clinical practice. METHODS HIV-1-infected children received efavirenz capsules or tablets in accordance with… Expand
Incidence and clinical features of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) and spectrum of mevalonate kinase (MVK) mutations in German children
Autoinflammatory diseases (AIDs) are characterized by recurrent, self-limiting systemic inflammation. Disorders include hereditary recurrent fever (HRF) syndromes such as hyperimmunoglobulinemia D… Expand
Clinical and functional characterisation of a novel TNFRSF1A c.605T>A/V173D cleavage site mutation associated with tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS),…
- S. Stojanov, C. Dejaco, +5 authors M. Schirmer
- Annals of the rheumatic diseases
- 30 November 2007
OBJECTIVES To study the clinical outcome, treatment response, T-cell subsets and functional consequences of a novel tumour necrosis factor (TNF) receptor type 1 (TNFRSF1A) mutation affecting the… Expand
Incidence of TNFRSF1A mutations in German children: epidemiological, clinical and genetic characteristics.
OBJECTIVE TNF receptor 1-associated periodic syndrome (TRAPS) is a rare disease belonging to the heterogeneous group of hereditary periodic fever (HPF) syndromes. By their monogenic origins, the HPF… Expand
Botulinum toxin type A and B for the reduction of hypersalivation in children with neurological disorders: a focus on effectiveness and therapy adherence.
Botulinum toxin (BoNT) is an established treatment option to reduce hypersalivation in children with chronic neurological disorders. Objective of this study was (1) to discriminate differences in… Expand
TNFRSF1A and MEFV mutations in childhood onset multiple sclerosis.
- A. Blaschek, Rüdiger V Kries, +6 authors T. Kümpfel
- European journal of paediatric neurology : EJPN…
To investigate frequency and phenotype of TNFRSF1A and MEFV mutations in childhood-onset multiple sclerosis (MS). Twenty-nine clinically well characterized patients were investigated for mutations in… Expand
Ten-year follow-up in a case series of integrative botulinum toxin intervention in adolescents with chronic daily headache and associated muscle pain.
INTRODUCTION A total of 83% of children report headache during a 6-month period. The estimated 1-year prevalence of chronic daily headache (CDH) in children is at least 1 to 2%. Muscle pain is… Expand
Unrestricted Weight Bearing and Intensive Physiotherapy after Uncemented Total Hip Arthroplasty
Background and Aims: The effectiveness of partial weightbearing after hip surgery has been questioned as well as the need of intensive physiotherapy. Material and Methods: 36 patients (average age… Expand