Kristina Bozhinova

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OBJECTIVE To explore the ability of the nonparametric expectation maximisation (NPEM) method of population pharmacokinetic modelling to deal with sparse data in estimating systemic caffeine clearance for monitoring and evaluation of cytochrome P450 (CYP) 1A2 activity. DESIGN AND PARTICIPANTS Nonblind, single-dose clinical investigation in 34 non-related(More)
OBJECTIVE To assess the average bioequivalence of two formulations of metformin after single-dose administration of each treatment to healthy subjects under fasting conditions by assessing the pharmacokinetic measures of systemic exposure and evaluating the confidence intervals (CIs) for each pharmacokinetic parameter. DESIGN Randomised, comparative,(More)
The complex formed between an anionic chelate of Mo(VI)-3,5-dinitrocatechol (3,5-DNC) with the cation of 3,3'-(3,3'-dimethoxy-4,4'-biphenylene)bis(2,5-diphenyl-2H-tetrazolium chloride) (Blue Tetrazolium Chloride, BTC) in the liquid-liquid extraction system Mo(VI)-3,5-DNC-BTC-H2O-CHCl3 was studied. The optimum conditions for the complex formation and(More)
OBJECTIVES To assess the average bioequivalence of two oral dosage forms of fluconazole--test (Fungolon, Antibiotic Co.) and reference (Diflucan, Pfizer)--in 18 healthy volunteers in a multiple dose-balanced, two-period, crossover study design. MATERIALS AND METHODS The dosage regimen consisted of seven days treatment (first day 100 mg and 50 mg(More)
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