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Evolution of GPCR: Change and continuity
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Reduced Food Intake and Body Weight in Mice Deficient for the G Protein-Coupled Receptor GPR82
TLDR
The data suggest that GPR82 function influences food intake and, therefore, energy and body weight balance, and may represent a thrifty gene most probably representing an advantage during human expansion into new environments.
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Signatures of Natural Selection at the FTO (Fat Mass and Obesity Associated) Locus in Human Populations
TLDR
Signals of balancing selection at the FTO locus with a prominent signal in intron three, a genomic region with strong association with BMI in the Sorbs support the hypothesis that genes associated with obesity may have been under evolutionary selective pressure.
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The evolution of the repertoire and structure of G protein-coupled receptors
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