Kristin M. O’Brien

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State III respiration rates were measured in mitochondria isolated from hearts of Antarctic notothenioid fishes that differ in the expression of hemoglobin (Hb) and myoglobin (Mb). Respiration rates were measured at temperatures between 2 and 40°C in Gobionotothen gibberifrons (+Hb/+Mb), Chaenocephalus aceratus (–Hb/–Mb) and Chionodraco rastrospinosus(More)
Previous work in our laboratory showed that levels of oxidized proteins and/or lipids increase in heart ventricles of icefishes but not red-blooded notothenioids in response to exposure to their critical thermal maxima (CTMax). However, neither icefishes nor red-blooded fishes up-regulate their antioxidant defenses in response to exposure to CTMax,(More)
Background: Interstitial flow in and around tumour tissue not only has particular importance in delivering anticancer agents to tumour tissue, but also affects the microenvironment to modulate tumour cell growth and metastasis. We investigated the roles of flow-induced shear stress in modulating radiosensitivity in two colon cancer cell lines and the(More)
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