Kristin Lee

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Localized accessibility of critical DNA sequences to the regulatory machinery is a key requirement for regulation of human genes. Here we describe a high-resolution, genome-scale approach for quantifying chromatin accessibility by measuring DNase I sensitivity as a continuous function of genome position using tiling DNA microarrays (DNase-array). We(More)
BACKGROUND Conserved non-coding sequences in the human genome are approximately tenfold more abundant than known genes, and have been hypothesized to mark the locations of cis-regulatory elements. However, the global contribution of conserved non-coding sequences to the transcriptional regulation of human genes is currently unknown. Deeply conserved(More)
A dredge-based sea scallop (Placopecten magellanicus) survey of Maine state waters ( 3 nm from shore) has been conducted since 2002 (with the exception of 2004). This annual survey provides information on size distribution, the shell height-meat weight relationship, abundance, stock size and spatial distribution of scallops from near shore waters along the(More)
OBJECTIVE The aims of the current study were to determine whether children with the 6 different APOE ε genotypes show differences in gray matter maturation, particularly for those with ε4 and ε2 alleles, which are associated with poorer outcomes in many neurologic disorders. METHODS A total of 1,187 healthy children (aged 3-20 years, 52.1% boys, 47.9%(More)
Genetic variations in ERBB4 were associated with increased susceptibility for schizophrenia (SCZ) and bipolar disorders (BPD). Structural imaging studies showed cortical abnormalities in adolescents and adults with SCZ or BPD. However, less is known about subclinical cortical changes or the influence of ERBB4 on cortical development. 971 healthy children(More)
This paper follows earlier work aimed at ensuring a connection between the information sharing needs of a large number of participants comprising a distributed command, control, and coordination network and the underlying communications capabilities that they possess; and on the relational model and database built as part of a subsequent effort to analyze(More)
Localized accessibility of critical DNA sequences to the regulatory machinery is a key requirement for regulation of human genes. Here we describe a high-resolution, genome-scale approach for quantifying chromatin accessibility by measuring DNase I sensitivity as a continuous function of genome position using tiling DNA microarrays (DNase-array). We(More)
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