Kristin J Lee

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Localized accessibility of critical DNA sequences to the regulatory machinery is a key requirement for regulation of human genes. Here we describe a high-resolution, genome-scale approach for quantifying chromatin accessibility by measuring DNase I sensitivity as a continuous function of genome position using tiling DNA microarrays (DNase-array). We(More)
OBJECTIVE The aims of the current study were to determine whether children with the 6 different APOE ε genotypes show differences in gray matter maturation, particularly for those with ε4 and ε2 alleles, which are associated with poorer outcomes in many neurologic disorders. METHODS A total of 1,187 healthy children (aged 3-20 years, 52.1% boys, 47.9%(More)
Conserved non-coding sequences in the human genome are approximately tenfold more abundant than known genes, and have been hypothesized to mark the locations of cis-regulatory elements. However, the global contribution of conserved non-coding sequences to the transcriptional regulation of human genes is currently unknown. Deeply conserved elements shared(More)
The selection of aminoacyl-tRNAs by the ribosome is a fundamental step in the elongation cycle of protein synthesis. tRNA selection is a multistep process that ensures only correct aminoacyl-tRNAs are accepted while incorrect aminoacyl-tRNAs are rejected. A key step in tRNA selection is the formation of base pairs between the anticodon of the aminoacyl-tRNA(More)
Low tidal volume/inspiratory pressure ventilator strategies result in hypercapnia, which has been shown to increase pulmonary vasomotor tone. This may be particularly detrimental in infants and children with preexistent pulmonary hypertension. In this study, a piglet model of chronic hypoxia-induced pulmonary hypertension was used to test the hypotheses(More)
OBJECTIVE Patients with knee osteoarthritis (OA) have been shown to have somatosensory deficits of the lower extremity. This study was designed to assess the association of these deficits with dynamic joint loading and their relationship to the structural and symptomatic severity of knee OA. METHODS Subjects with symptomatic knee OA underwent evaluation(More)
Recognition of stop codons by class I release factors is a fundamental step in the termination phase of protein synthesis. Since premature termination is costly to the cell, release factors have to efficiently discriminate between stop and sense codons. To understand the mechanism of discrimination between stop and sense codons, we developed a new,(More)
This paper follows earlier work aimed at ensuring a connection between the information sharing needs of a large number of participants comprising a distributed command, control, and coordination network and the underlying communications capabilities that they possess; and on the relational model and database built as part of a subsequent effort to analyze(More)
The Georgia Sea Turtle Center has a mission of conservation based rehabilitation, research, and education. Marine debris is a serious threat to marine species. In an effort to educate local students, the GSTC obtained a grant to provide educational opportunities to local third graders. Third and fourth grade classes in Glynn County, Georgia were offered a(More)