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PURPOSE Understanding the etiology of cancer-related fatigue (CRF) is critical to identify targets to develop therapies to reduce CRF burden. The goal of this systematic review was to expand on the initial work by the National Cancer Institute CRF Working Group to understand the state of the science related to the biology of CRF and, specifically, to(More)
BACKGROUND Although telomere shortening occurs as a natural part of aging, there is now a robust body of research that suggests that there is a relationship between psychosocial, environmental, and behavioral factors and changes in telomere length. These factors need to be considered when integrating telomere measurement in biobehavioral research studies.(More)
BACKGROUND The exciting discovery that telomere shortening is associated with many health conditions and that telomere lengths can be altered in response to social and environmental exposures has underscored the need for methods to accurately and consistently quantify telomere length. OBJECTIVES The purpose of this article is to provide a comprehensive(More)
Fatigue is often described by patients as a lack of energy, mental or physical tiredness, diminished endurance, and prolonged recovery after physical activity. Etiologic mechanisms underlying fatigue are not well understood; however, fatigue is a hallmark symptom of mitochondrial disease, making mitochondrial dysfunction a putative biological mechanism for(More)
Cancer-related fatigue (CRF) is a prominent and distressing symptom for cancer patients that can impair their overall health-related quality of life [1]. CRF is often described as a complex and multidimensional concept consisting of physical, cognitive, affective, spiritual, psychosocial, and environmental factors [1, 2]. Assessment of CRF is obtained from(More)
PURPOSE Mitochondrial dysfunction is a plausible biological mechanism for cancer-related fatigue. Specific aims of this study were to (1) describe the levels of mitochondrial oxidative phosphorylation complex (MOPC) enzymes, fatigue, and health-related quality of life (HRQOL) before and at completion of external beam radiation therapy (EBRT) in men with(More)
This article presents initial diagnostic workup and criteria for diagnosing solitary plasmacytoma of bone (SPB) versus multiple myeloma. The authors discuss the incorporation of current imaging technologies into the diagnosis and staging of SPB and multiple myeloma. In addition, the article addresses treatment modalities and discusses the importance of(More)
Falls are a major concern for patients with acute myeloid leukemia who are admitted to the hospital for induction chemotherapy. Patients with cancer are at risk for rapidly changing health status and, therefore, need a different kind of fall surveillance than those in other inpatient units. Fall risk most likely will change throughout an inpatient's stay.(More)
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