Kristian Johansen

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Experimental and clinical studies indicate that low molecular weight heparins (LMWH) may inhibit cancer and/or metastasis. The purpose of this study was to investigate whether it is possible to design non-anti-coagulant, anti-metastatic compounds based on heparin. The LMWH Tinzaparin and a series of non-anti-coagulant (NAC) heparin derivatives, varying in(More)
The contamination of the widely used lifesaving anticoagulant drug heparin in 2007 has drawn renewed attention to the challenges that are associated with the characterization, quality control and standardization of complex biological medicines from natural sources. Heparin is a linear, highly sulfated polysaccharide consisting of alternating glucosamine and(More)
Since low-molecular-weight heparins (LMWHs) are eliminated preferentially via the kidneys, the potential for accumulation of these agents (and an increased risk of bleeding) is of particular concern in populations with a high prevalence of renal impairment, such as the elderly and patients with cancer. The risk of clinically relevant accumulation of(More)
Plasma lipoproteins were measured in seven healthy breast-fed infants three times during the first and on the third, sixth and twenty-first days of life. Plasma total beta-lipoprotein, very low density and low density lipoprotein increased three times during the first week of life. Plasma total apolipoprotein A-I and high density lipoprotein increased twice(More)
Protamine sulphate is an effective inhibitor of heparin and is used clinically to neutralise both low molecular weight heparins (LMWH) and unfractionated heparin (UFH). However, protamine sulphate does not fully counter the anti-Xa effect of LMWH, even in excess (>40 μg to 1 IU/ml). To investigate the molecular basis for this observation, the residual(More)
A method for the determination of angiotensin-converting enzyme in serum (S-ACE; EC with use of 3-(2-furylacryloyl)-L-phenylalanyl-glycyl-glycine (FAPGG) as substrate has been adapted for the Cobas Bio microcentrifugal analyser. The method allows 24 determinations per hour in a sample volume of 28 microliters with a within run precision of less(More)
We are developing an approach to organizing bookmarks and other information resources by annotating them with metadata in the form of synsets taken from WordNet. This paper shows how a collection of annotated bookmarks can be semantically enriched by adding hyper-/hyponym relations from WordNet. It then illustrates how the semantically enriched bookmark(More)
The content of free and esterified cholesterol in serum low density lipoprotein (LDL) was measured in 19 children with heterozygous familial hypercholesterolemia (FH) and in 10 normal siblings. In FH both free and esterified cholesterol were found to be elevated. Furthermore the fatty acid composition of serum LDL- and lymphocyte cholesterol esters was(More)