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Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases.
Cellular DNA damage causes stabilization and activation of the tumor suppressor and transcription factor p53, in part by promoting multiple covalent modifications of the p53 protein, including… Expand
Matrix Regulation of Skeletal Cell Apoptosis
- C. S. Adams, K. Mansfield, R. L. Perlot, I. Shapiro
- Medicine, Biology
- The Journal of Biological Chemistry
- 8 June 2001
Previously, we noted that inorganic phosphate (Pi), a major component of bone extracellular matrix, induced osteoblast apoptosis (Meleti, Z., Shapiro, I. M., and Adams, C. S. (2000) Bone (NY) 27,… Expand
Adhesion to substrates induces dendritic cell endothelization and decreases immunological response.
Dendritic cells (DCs) are antigen presenting cells capable of inducing specific immune responses against microbial infections, transplant antigens, or tumors. DCs have been shown to possess a high… Expand
Hypoxia, HIFs, and cardiovascular development.
The interplay between surfaces and soluble factors define the immunologic and angiogenic properties of myeloid dendritic cells
BackgroundDendritic cells (DCs) are antigen presenting cells capable of inducing specific immune responses against microbial infections, transplant antigens, or tumors. Interestingly,… Expand