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The Drosophila neuromuscular junction (NMJ) is an established model system used for the study of synaptic development and plasticity. The widespread use of the Drosophila motor system is due to its high accessibility. It can be analyzed with single-cell resolution. There are 30 muscles per hemisegment whose arrangement within the peripheral body wall are(More)
The Drosophila neuromuscular junction (NMJ) is an established model system used for the study of synaptic development and plasticity. The widespread use of the Drosophila motor system is due to its high accessibility. It can be analyzed with single-cell resolution. There are 30 muscles per hemisegment whose arrangement within the peripheral body wall are(More)
ii This document is in the public domain and may be used and reprinted without special permission. Citation of the source is appreciated. One of the key factors driving the adoption and appropriate utilization of electronic health record (EHR) systems is their usability. 1 However, a recent study funded by the Agency for Healthcare Research and Quality(More)
HEALTH IT ii This document is in the public domain and may be used and reprinted without special permission. Citation of the source is appreciated. Preface To support research and policy formation in the area of Electronic Health Record (EHR) usability, the Agency for Healthcare Research and Quality (AHRQ) commissioned the " Use of Dense Display and(More)
Alpha/beta interferons (IFN-alpha/beta) are key mediators of innate immunity and important modulators of adaptive immunity. The mechanisms by which IFN-alpha/beta are induced are becoming increasingly well understood. Recent studies showed that Toll-like receptors 7 and 8 expressed by plasmacytoid dendritic cells (pDCs) mediate the endosomal recognition of(More)
HEALTH IT ii This document is in the public domain and may be used and reprinted without special permission. Citation of the source is appreciated. Preface To support research and policy formation in the area of Electronic Health Record (EHR) usability, the Agency for Healthcare Research and Quality (AHRQ) commissioned the " Use of Dense Display and(More)
A molecular understanding of synaptogenesis is a critical step toward the goal of understanding how brains "wire themselves up," and then "rewire" during development and experience. Recent genomic and molecular advances have made it possible to study synaptogenesis on a genomic scale. Here, we describe the results of a screen for genes involved in formation(More)
Exposure to cigarette smoke has long been linked to carcinogenesis, but the emphasis has been placed on mutational changes in the DNA sequence caused by the carcinogens in smoke. Here, we report an additional role for cigarette smoke exposure in contributing to chromosomal aberrations in cells. We have found that cigarette smoke condensate (CSC) induces(More)
An understanding of the balance of chemical forces responsible for protein stability and specificity of structure is essential for the success of efforts in protein design. Specifically, electrostatic interactions between charged amino acids have been explored extensively to understand the contribution of this force to protein stability. Much research on(More)
In a process known as quorum sensing, bacteria use chemicals called autoinducers for cell-cell communication. Population-wide detection of autoinducers enables bacteria to orchestrate collective behaviors. In the animal kingdom detection of chemicals is vital for success in locating food, finding hosts, and avoiding predators. This behavior, termed(More)