Kristen M Turner

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BACKGROUND Cardiovascular disease is an important cause of morbidity and mortality in sickle cell disease (SCD). We sought to characterize sickle cell cardiomyopathy using multimodality noninvasive cardiovascular testing and identify potential causative mechanisms. METHODS AND RESULTS Stable adults with SCD (n=38) and healthy controls (n=13) prospectively(More)
BACKGROUND Regadenoson is a vasodilator stress agent that selectively activates the A2A receptor. Compared to adenosine, regadenoson is easier to administer and results in fewer side effects. Although extensively studied in patients undergoing nuclear perfusion imaging (MPI), its use for perfusion cardiovascular magnetic resonance (CMR) is not well(More)
Background Regadenoson (Lexiscan; Astellas) is a new vasodilator myocardial stress agent that selectively activates the A2A receptor. Unlike adenosine, regadenoson is easier to administer and results in fewer side effects. Although extensively studied in patients undergoing nuclear myocardial perfusion imaging (MPI), its performance in cardiovascular(More)
Background Abnormalities in total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides (TG) are associated with microvascular dysfunction and are the primary target for treating atherosclerosis. Newer lipid assays allow for measurements of lipoprotein sub-fractions; however, their impact on microvascular(More)
Methods Thirty-one stable, African-American outpatients with SCD (mean age 32±8 yrs) prospectively underwent CMR (Philips 1.5 Tesla) and TTE (Philips iE33). Retrospectivelygated cines of left ventricular (LV) 2-, 3-, and 4-chamber, and short axis cine stack were obtained using SSFP (temporal resolution 25-40ms). Late gadolinium enhancement (LGE) images of(More)
Background Abnormalities in total cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), and triglycerides (TG) are associated with microvascular dysfunction. Recent studies suggest that lipoprotein sub-fractions better predict atherogenic burden than a routine lipid panel. We sought to determine, whether lipid(More)
We sought to characterize the features of sickle cell cardiomyopathy and to identify causative mechanisms using comprehensive cardiac magnetic resonance, echocardiography, and arterial tonometry. We found that sickle cell cardiomyopathy is characterized by 4-chamber dilation, myocardial fibrosis, abnormal myocardial perfusion reserve, diastolic dysfunction,(More)
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