Novel changes in gene expression following axotomy of a sympathetic ganglion: a microarray analysis.
- K. BoeshoreR. Schreiber R. Zigmond
- 1 May 2004
Biology, Medicine
DNA microarray technology was used to study changes in gene expression within 48 h of transecting the postganglionic trunks of the adult rat superior cervical ganglion and suggested a potential role for putrescine and spermidine, acting downstream of arg I, in the regenerative process.
TrkB Isoforms with Distinct Neurotrophin Specificities Are Expressed in Predominantly Nonoverlapping Populations of Avian Dorsal Root Ganglion Neurons
- K. BoeshoreC. LuckeyR. ZigmondT. Large
- 15 June 1999
Biology
The predominant expression pattern of either FL or ED isoforms in single embryonic DRG neurons establishes the existence of two subpopulations exhibiting differential responsiveness to trkB ligands, indicating that regulated splicing of the extracellular domain of trkB may serve as a mechanism to restrict neuronal responsiveness to the neurotrophins.
Neural differentiation promoted by truncated trkC receptors in collaboration with p75(NTR).
- S. J. HapnerK. BoeshoreT. LargeT. LargeF. Lefcort
- 1 September 1998
Biology, Medicine
A phenotypic response to activation of the trkC TK- receptor is identified and a functional interaction with p75(NTR) neurotrophin receptor is demonstrated, indicating there may be multipletrkC receptor-mediated systems guiding neuronal differentiation.
A comparison of the changes in the non-neuronal cell populations of the superior cervical ganglia following decentralization and axotomy.
- R. SchreiberS. A. VaccarielloK. BoeshoreA. ShadiackR. Zigmond
- 1 October 2002
Biology, Medicine
Future studies must address what role(s) infiltrating and/or resident macrophages play in regions of decentralized and axotomized neurons and, if both are involved, whether they play distinct roles.
Polyamines increase in sympathetic neurons and non-neuronal cells after axotomy and enhance neurite outgrowth in nerve growth factor-primed PC12 cells
- R. SchreiberK. BoeshoreG. LaubeR. VehR. Zigmond
- 31 December 2004
Biology, Medicine
Cocaine promotes primary human astrocyte proliferation via JNK-dependent up-regulation of cyclin A2.
- Chun-Ting LeeK. Boeshore W. Freed
- 2016
Medicine, Biology
Cocaine-induced abnormal increases in the number of astrocytes may cause disruption in neuron-glia signaling and contribute to synaptic impairment in the CNS, and understanding the mechanisms of cocaine's effects on human astroCytes may help to reveal the involvement of glial cells in addictive behaviors.
List of contributors
- C. Barragán-ÁlvarezLaura Bernardini M. Ziller
- 2022
Medicine, Engineering
Novel Concepts in iPSC Disease Modeling
Applications of human induced pluripotent stem cell and human embryonic stem cell models for substance use disorders
- K. BoeshoreChun-Ting LeeW. Freed
- 2022
Medicine
Novel Concepts in iPSC Disease Modeling