Kristen K. Briggs

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Full thickness defects of the articular cartilage rarely heal spontaneously. While some patients do not develop clinically significant problems from chondral defects, most eventually develop degenerative changes associated with the cartilage damage over time. Techniques to treat chondral defects include abrasion, drilling, tissue autografts, allografts, and(More)
OBJECTIVE To determine the in vivo biocompatibility of septal neocartilage constructs developed in vitro by an alginate intermediate step. STUDY DESIGN Prospective, animal model. SETTING Research laboratory. SUBJECTS AND METHODS A murine model was used to examine the maturation of neocartilage constructs in vivo. Chondrocytes collected from patients(More)
OBJECTIVES (1) To show that extracellular matrix deposition in 3-dimensional culture of human septal chondrocytes cultured in a rotary bioreactor is comparable to the deposition achieved under static culture conditions. (2) To demonstrate that the biomechanical properties of human septal chondrocytes cultured in a bioreactor are enhanced with time and are(More)
OBJECTIVES/HYPOTHESIS Tissue-engineered septal cartilage may provide a source of autologous cartilage for repair of nasal defects. Production of clinically useful neocartilage involves multiple steps that include manipulating the culture environment. Partial pressure of oxygen (ppO(2) ) is a property that has been shown to influence cartilage development.(More)
OBJECTIVES/HYPOTHESIS To localize quantitatively the major biochemical constituents of native adult human septal cartilage across whole septa. STUDY DESIGN Prospective, basic science. METHODS The nasal septa from seven cadavers were partitioned into 24 separate regions: six from caudal to cephalic and four from dorsal to ventral. Biochemical assays were(More)
IMPORTANCE Cartilaginous craniofacial defects range in size and autologous cartilaginous tissue is preferred for repair of these defects. Therefore, it is important to have the ability to produce large size cartilaginous constructs for repair of cartilaginous abnormalities. OBJECTIVES To produce autologous human septal neocartilage constructs(More)
OBJECTIVES Structural properties of tissue-engineered cartilage can be optimized by altering its collagen to sulfated glycosaminoglycan (sGAG) ratio with hyaluronidase. The objective was to determine if treatment of neocartilage constructs with hyaluronidase leads to increased collagen:sGAG ratios, as seen in native tissue, and improved tensile properties.(More)
Tissue-engineered nasal septal cartilage may provide a source of autologous tissue for repair of craniofacial defects. Although advances have been made in manipulating the chondrocyte culture environment for production of neocartilage, consensus on the best oxygen tension for in vitro growth of tissue-engineered cartilage has not been reached. The objective(More)
Irreparable Labrumrupturen und -defektzustände können zu anhaltenden Schmerzen und einer progredienten Degeneration des Hüftgelenks führen. Die arthroskopische Labrumrekonstruktion mit Autotransplantation eines Tractus-iliotibialis-Streifens stellt eine Behandlungsoption bei ausgewählten Patienten dar. Die ersten Ergebnisse von 37 Patienten bei mindestens(More)
OBJECTIVES Evaluate safety of autogenous engineered septal neocartilage grafts.Compare properties of implanted grafts versus in vitro controls. STUDY DESIGN Prospective, basic science. SETTING Research laboratory. METHODS Constructs were fabricated from septal cartilage and serum harvested from adult rabbits and then cultured in vitro or implanted on(More)