Kristen K.B. Barthel

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The host factor, nuclear factor of activated T-cells (NFAT), regulates the transcription and replication of HIV-1. Here, we have determined the crystal structure of the DNA binding domain of NFAT bound to the HIV-1 long terminal repeat (LTR) tandem kappaB enhancer element at 3.05 A resolution. NFAT binds as a dimer to the upstream kappaB site (Core II), but(More)
Darren L. Bates,1 Kristen K.B. Barthel,1 Yongqing Wu,2 Reza Kalhor,2 James C. Stroud,1 Michael J. Giffin,1 and Lin Chen2,* 1Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309-0215, USA 2Molecular and Computational Biology, Department of Chemistry, Norris Cancer Center, University of Southern California, Los(More)
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