Kristen Hokenson

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Tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABARs) sensing ambient levels of GABA can profoundly alter the membrane input resistance to affect cellular excitability. Therefore, regulation of tonic inhibition is an attractive mechanism to control the levels of cortical firing. In cortical pyramidal cells, tonic inhibition is regulated by(More)
The Spike Histogram Software In the context of this undergraduate neurophysiology lab, the recording and analysis of neural activity is essential in conveying an understanding of the mechanisms involved in producing such activity. This recording is especially important in analyzing the crayfish swimmeret system, in which identifying patterns of neural(More)
General anaesthetics are proposed to cause unconsciousness by modulating neuronal excitability in the mammalian brain through mechanisms that include enhancement of inhibitory GABA(A) receptor currents and suppression of excitatory glutamate receptor responses. Both intravenous and volatile agents may produce neurotoxic effects during early postnatal rodent(More)
Neuroactive steroids are produced de novo in the central nervous system and have been shown to regulate neuronal excitability and synaptic plasticity. Increasing evidence suggests that neurosteroids and neuroactive steroids such as pregnenolone and its metabolite pregnenolone sulfate (PregS) are implicated in the pathophysiology of neuropsychiatric(More)
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