Kristen G Williams

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We investigated the microglial response to progressive dopamine neuron degeneration using in vivo positron emission tomography (PET) imaging and postmortem analyses in a Parkinson's disease (PD) rat model induced by unilateral (right side) intrastriatal administration of 6-hydroxydopamine (6-OHDA). Degeneration of the dopamine system was monitored by PET(More)
OBJECTIVE This study sought to examine the effects of a 3-month programme of dietary advice to restrict carbohydrate intake compared with reduced-portion, low-fat advice in obese subjects with poorly controlled Type 2 diabetes. RESEARCH DESIGN AND METHODS One hundred and two patients with Type 2 diabetes were recruited across three centres and randomly(More)
Depression during the perinatal period is common, debilitating, and consequential for women and their children, particularly among low income African American women. Viable approaches to prevention of depression have emerged. Yet little is known about women's preferences for approaches to preventing depression. A sample of 60 pregnant, low-income African(More)
BACKGROUND Alström syndrome is an autosomal recessive condition characterized by obesity, insulin resistance and hypertriglyceridaemia. Responses to fat and carbohydrate ingestion are important in planning dietetic advice and may help to explain the mechanism of metabolic disorder in the syndrome. METHODS After a 12-h fast, five Alström subjects received(More)
Yearly there are 26,000 collisions involving school-buses with approximately 17,000 resulting injuries. According to the National Highway Transportation and Safety Administration, 96% of these injuries are minor or moderate. This injury data is an estimate derived from a national probability sample. Although most injuries are not critical, issues of(More)
Isolated papillary muscles from young dogs were studied to determine the feasibility of utilizing plasma, without added foam depressants, as a test solution to support muscle function. Diluted canine plasma, undiluted canine plasma, plasma with adjusted protein content, monkey plasma, and plasma containing myocardial depressant factors (MDF) were evaluated.(More)
namely, a low family income and lack of a confidant. There was no interaction between these two factors in their effect. The logistic regression of probability (case)/probability (non-case) on income and the presence of a confidant showed a good fit with an additive model, the mean (SE) estimates for their effects being 1-16 (0 45) and 1-80 (0-59)(More)
The occurrence of tumor immunity in mice bearing a growing plasmacytoma (PC) was studied by local adoptive transfer assay. Spleen cells from mice with a large PC but not with a nonpalpable or small PC retarded and often inhibited entirely the growth of homologous PC. They occasionally caused late regression of growing homologous and heterologous PC. The(More)
Alström syndrome (OMIM 203800) is an autosomal recessive condition caused by pathological mutations in the ALMS1 gene of worldwide distribution prevalence. 200 subjects and longitudinal in depth studies of the UK cohort of 100 subjects have highlighted the extreme variation not only in the rate of visual and hearing loss but also in extent and progression(More)
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