Kristen A. Baltgalvis

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BACKGROUND Cachexia involves unintentional body weight loss including diminished muscle and adipose tissue mass and is associated with an underlying disease. Systemic overexpression of IL-6 accelerates cachexia in the Apc(Min/+) mouse, but does not induce wasting in control C57BL/6 mice. With many chronic diseases, chronic inflammation and metabolic(More)
The Apc Min/+ mouse has a mutation in the Apc tumor suppressor gene and develops intestinal polyps, beginning at 4 weeks of age. This mouse develops cachexia by 6 months, characterized by significant loss of muscle and fat tissue. The purpose of the present study was to determine the role of circulating IL-6 and the polyp burden for the development of(More)
Aging can alter the skeletal muscle growth response induced by overload. The initiation of overload induces muscle extracellular matrix expansion, increased cellularity, and inflammatory gene expression, which are all related to processes important for myofiber growth. These remodeling processes are also biological targets of testosterone. It is not certain(More)
OBJECTIVES The purpose of this study was to determine the extent to which prednisolone treatment and restricted physical activity caused deleterious changes in inherently compromised mdx bone. METHODS Four week-old male mdx mice (n=36) were treated for 8-wk either with or without prednisolone (0.8-1.3 mg/kg/d) and were housed in traditional or small cages(More)
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