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Distinct regions within the GluN2C subunit regulate the surface delivery of NMDA receptors
N-methyl-D-aspartate (NMDA) receptors mediate fast excitatory synaptic transmission in the mammalian central nervous system. The activation of NMDA receptors plays a key role in brain development,Expand
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Two N-glycosylation Sites in the GluN1 Subunit Are Essential for Releasing N-methyl-d-aspartate (NMDA) Receptors from the Endoplasmic Reticulum*
Background: Regulation of NMDA receptors is critical for excitatory neurotransmission. Results: N-glycans are essential for NMDA receptor release from the endoplasmic reticulum and for receptorExpand
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Cholinergic properties of new 7-methoxytacrine-donepezil derivatives.
Organophosphorus nerve agents inhibit acetylcholinesterase (AChE) which causes the breakdown of the transmitter acetylcholine (ACh) in the synaptic cleft. Overstimulation of cholinergic receptorsExpand
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Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease.
A novel molecule 2 formed by combining 6-chlorotacrine (6-Cl-THA) and memantine proved to be a promising multipotent hybrid capable of blocking the action of acetylcholinesterase (AChE) as well asExpand
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Biochemical and electrophysiological characterization of N‐glycans on NMDA receptor subunits
In mammals, excitatory synapses contain two major types of ionotropic glutamate receptors: α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptors and N‐methyl‐d‐aspartate receptors (NMDARs).Expand
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N-Glycosylation Regulates the Trafficking and Surface Mobility of GluN3A-Containing NMDA Receptors
N-methyl-D-aspartate receptors (NMDARs) play critical roles in both excitatory neurotransmission and synaptic plasticity. NMDARs containing the nonconventional GluN3A subunit have differentExpand
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Different effects of lobeline on neuronal and muscle nicotinic receptors.
Lobeline is a plant alkaloid known to interact with cholinergic system. The effect of lobeline on neuronal α3β4 receptors expressed in COS cells and muscle embryonic αβγδ receptors naturallyExpand
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Lectins modulate the functional properties of GluN1/GluN3-containing NMDA receptors
N-methyl-d-aspartate receptors (NMDARs) play an essential role in excitatory neurotransmission within the mammalian central nervous system (CNS). NMDARs are heteromultimers containing GluN1, GluN2,Expand
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Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors
N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors that play an essential role in mediating excitatory neurotransmission in the mammalian central nervous system (CNS).Expand
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Cholesterol modulates presynaptic and postsynaptic properties of excitatory synaptic transmission
Cholesterol is a structural component of cellular membranes particularly enriched in synapses but its role in synaptic transmission remains poorly understood. We used rat hippocampal cultures andExpand
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