Krishnan B. Chandran

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The relationships among vascular geometry, hemodynamics, and plaque development in the coronary arteries are complex and not yet well understood. This paper reports a methodology for the quantitative analysis of in vivo coronary morphology and hemodynamics, with particular emphasis placed on the critical issues of image segmentation and the automated(More)
Identification of anatomical features is a necessary step for medical image analysis. Automatic methods for feature identification using conventional pattern recognition techniques typically classify an object as a member of a predefined class of objects, but do not attempt to recover the exact or approximate shape of that object. For this reason, such(More)
Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works, must be obtained from the IEEE. ABSTRACT A common hypothesis is(More)
Quantitative evaluation of cardiac function from cardiac images requires the identification of the myocardial walls. This generally requires the clinician to view the image and interactively trace the contours. This method is susceptible to great variability that depends on the experience and knowledge of the particular operator tracing the contours. The(More)
The mitral valve (MV) apparatus consists of the two asymmetric leaflets, the saddle-shaped annulus, the chordae tendineae, and the papillary muscles. MV function over the cardiac cycle involves complex interaction between the MV apparatus components for efficient blood circulation. Common diseases of the MV include valvular stenosis, regurgitation, and(More)
The relationships among vascular geometry, hemodynamics, and plaque development in coronary arteries are not yet well understood. This in-vivo study was based on the observation that plaque frequently develops at the inner curvature of a vessel, presumably due to a relatively lower wall shear stress. We have shown that circumferential plaque distribution(More)
A Parallelized sharp-interface fixed grid method for moving boundary problems. 1 ABSTRACT The primary objective of this thesis is to develop a general computational framework to perform large scale moving boundary problems in fluid mechanics. The interactions of moving entities with fluid flow are common to numerous engineering and biomedical applications.(More)
  • Y Rim, S T Laing, P Kee, K B Chandran, D D Mcpherson, H Kim
  • 2011
Abnormal mitral valve (MV) morphology may lead to high stress generation. Computational simulation of the MV apparatus may help us better understand and characterize the biomechanics and physiology of MV function and disease-related alterations. The MV apparatus geometry was identified using three-dimensional (3D) transesophageal echocardiographic (TEE)(More)
PURPOSE To investigate the cause and clinical significance of arterial enhancement (AE) in contrast-enhanced T1-weighted MR examinations after acute cerebral ischemia. METHODS Contrast MR examinations and conventional angiograms of 17 patients studied following an acute ischemic event or an internal carotid occlusion were retrospectively reviewed. MR and(More)