Krishnamurthi Kannan

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Oxidative stress is reported to negatively affect osteoblast cells. Present study reports oxidative and inflammatory signatures in fluoride-exposed human osteosarcoma (HOS) cells, and their possible association with the genes involved in osteoblastic differentiation and bone development pathways. HOS cells were challenged with sublethal concentration (8(More)
Fluorosis is caused by excess of fluoride intake over a long period of time. Aberrant change in the Runt-related transcription factor 2 (RUNX2) mediated signaling cascade is one of the decisive steps during the pathogenesis of fluorosis. Up to date, role of fluoride on the epigenetic alterations is not studied. In the present study, global expression(More)
Endosulfan, an organochlorine pesticide, is known to induce multiple disorders/abnormalities including neuro-degenerative disorders in many animal species. However, the molecular mechanism of endosulfan induced neuronal alterations is still not well understood. In the present study, the effect of sub-lethal concentration of endosulfan (3 μM) on human(More)
Design considerations of a database computer are presented in this paper. The overall architecture of the computer as well as the organization of its individual components are discussed. Several key concepts which are vital to database management are incorporated in the design and organization of the components. The concepts of tracks-in-parallel read-out(More)
Biological CO(2) sequestration using algal reactors is one of the most promising and environmentally benign technologies to sequester CO(2). This research study was taken up to alleviate certain limitations associated with the technology such as low CO(2) sequestration efficiency and low biomass yields. The study demonstrates an increase in CO(2)(More)
Recent developments in storage technologies have given computer system designers a wide range to consider in building large on-line systems. It is important that the requirements of each component of a proposed system be carefully recognized before choosing a particular technology for its implementation. The design of a database computer which takes(More)
The design of a microprogrammable microprocessor-based keyword transformation unit for a database computer(DBC) is described. The DBC, a specialized back-end computer capable of managing 10<supscrpt>9</supscrpt> - 10<supscrpt>10</supscrpt> bytes of data, consists of two loops of memories and processors, the structure loop and the data loop, connected(More)
Manganese (Mn) is an essential trace element required for optimal functioning of cellular biochemical pathways in the central nervous system. Elevated exposure to Mn through environmental and occupational exposure can cause neurotoxic effects resulting in manganism, a condition with clinical symptoms identical to idiopathic Parkinson’s disease. Epigenetics(More)
The study was conducted to isolate endosulfan biotransforming or biodegrading microbes based on chemotaxis. Pseudomonas aeruginosa strain KKc3, Ochrobactrum sp. strain KKc4, Achromobacter xylosoxidans strain KKc6 and Bacillus megaterium KKc7 were isolated based on their migration towards endosulfan in a soil column. Out of the four bacteria, B. megaterium(More)