Krishnamurthi Kannan

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Recent developments in storage technologies have given computer system designers a wide range to consider in building large on-line systems. It is important that the requirements of each component of a proposed system be carefully recognized before choosing a particular technology for its implementation. The design of a database computer which takes(More)
The design of a microprogrammable microprocessor-based keyword transformation unit for a database computer(DBC) is described. The DBC, a specialized back-end computer capable of managing 10<supscrpt>9</supscrpt> - 10<supscrpt>10</supscrpt> bytes of data, consists of two loops of memories and processors, the structure loop and the data loop, connected(More)
The motivation for seeking hardware solutions to database management functions traditionally carried out by software has been apparent to data-base designers for sometime now. Firstly, database management software has grown in complexity and size over the years. This growth is prompted by the increase in user requirements, by the formulation of(More)
Fluorosis is caused by excess of fluoride intake over a long period of time. Aberrant change in the Runt-related transcription factor 2 (RUNX2) mediated signaling cascade is one of the decisive steps during the pathogenesis of fluorosis. Up to date, role of fluoride on the epigenetic alterations is not studied. In the present study, global expression(More)
Manganese (Mn) is an essential trace element required for optimal functioning of cellular biochemical pathways in the central nervous system. Elevated exposure to Mn through environmental and occupational exposure can cause neurotoxic effects resulting in manganism, a condition with clinical symptoms identical to idiopathic Parkinson’s disease. Epigenetics(More)
Oxidative stress is reported to negatively affect osteoblast cells. Present study reports oxidative and inflammatory signatures in fluoride-exposed human osteosarcoma (HOS) cells, and their possible association with the genes involved in osteoblastic differentiation and bone development pathways. HOS cells were challenged with sublethal concentration (8(More)
Enterobacteriaceae, one of the major families of microorganisms that inhabit the soil and gut, internally regulate constant fluctuations in soil and gut pH by buffering these changes through the presence of carbonic anhydrase (CA). In our study, we prove the prevalence of β-CA, derived from the can gene, in members of Enterobacteriaceae by using a(More)
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