Krishnakant G. Soni

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Lipid droplets (LDs) are cytoplasmic organelles that store neutral lipids for use as an energy supply in times of nutrient deprivation and for membrane assembly. Misregulation of LD function leads to many human diseases, including lipodystrophy, obesity and neutral lipid storage disorders. A number of proteins have been shown to localize to the surface of(More)
The Arf1 exchange factor GBF1 (Golgi Brefeldin A resistance factor 1) and its effector COPI are required for delivery of ATGL (adipose triglyceride lipase) to lipid droplets (LDs). Using yeast two hybrid, co-immunoprecipitation in mammalian cells and direct protein binding approaches, we report here that GBF1 and ATGL interact directly and in cells, through(More)
Andrew S Greenberg*, Fredric B Kraemer, Krishnakant G Soni, Mark P Jedrychowski, Qing-Wu Yan, Christine E Graham, Thomas A Bowman and Ayla Mansur Obesity and Metabolism Laboratory, JM-USDA HNRCA, Tufts University, Boston, MA, USA, Division of Endocrinology, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, USA and Department of Cell(More)
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