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The intracellular bacterium Francisella tularensis survives in mammals, arthropods, and freshwater amoeba. It was previously established that the conventional media used for in vitro propagation of this microbe do not yield bacteria that mimic those harvested from infected mammals; whether these in vitro-cultivated bacteria resemble arthropod- or(More)
The advent of Local Electrode Atom Probe (LEAP) tomography is revolutionizing materials science by enabling near atomic scale imaging of materials. Analysis of three-dimensional atom probe tomography (APT) data holds the promise of relating combinatorial arrangement of atoms to material properties and enable better design and synthesis of complex materials.(More)
Polyanhydrides are a promising class of biomaterials for use as vaccine adjuvants and as multi-component implants. Their properties can be tailored for such applications as controlled drug release, drug stability, and/or immune regulation (adjuvant effect). Understanding the induction of immunomodulatory mechanisms of this polymer system is important for(More)
The Akt signalling pathway is a crucial network of proteins, which plays a role in neonatal cellular proliferation, hypertrophy and cellular survival mechanism in the heart through a multifaceted system including, small non-coding RNAs (sncRNAs). Despite numerous reports on the distorted expression of these proteins in various cardiovascular diseases, this(More)
An opportunity exists today for cross-cutting research utilizing advances in materials science, immunology, microbial pathogenesis, and computational analysis to effectively design the next generation of adjuvants and vaccines. This study integrates these advances into a bottom-up approach for the molecular design of nanoadjuvants capable of mimicking the(More)
Techniques in materials design, immunophenotyping, and informatics can be valuable tools for using a molecular based approach to design vaccine adjuvants capable of inducing protective immunity that mimics a natural infection but without the toxic side effects. This work describes the molecular design of amphiphilic polyanhydride nanoparticles that activate(More)
—Field applications of existing sensing solutions to structural health monitoring (SHM) of civil structures are limited. This is due to economical and/or technical challenges in deploying existing sensing solutions to monitor geometrically large systems. To realize the full potential of SHM solutions, it is imperative to develop scalable cost-effective(More)
The myriad structural manifestations and their material properties have made carbon nanostructures very interesting not only for potential applications but also for understanding carbon at the atomic scale. Several different nano-sized structures of carbon have been investigated intensely. A few of these include single and multi-walled nanotubes, [1](More)