Krishna K. Saha

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We derive a first-order bias-corrected maximum likelihood estimator for the negative binomial dispersion parameter. This estimator is compared, in terms of bias and efficiency, with the maximum likelihood estimator investigated by Piegorsch (1990, Biometrics46, 863-867), the moment and the maximum extended quasi-likelihood estimators investigated by Clark(More)
The over-dispersion parameter is an important and versatile measure in the analysis of one-way layout of count data in biological studies. For example, it is commonly used as an inverse measure of aggregation in biological count data. Its estimation from finite data sets is a recognized challenge. Many simulation studies have examined the bias and(More)
Interval estimation of the proportion parameter in the analysis of binary outcome data arising in cluster studies is often an important problem in many biomedical applications. In this paper, we propose two approaches based on the profile likelihood and Wilson score. We compare them with two existing methods recommended for complex survey data and some(More)
Missing covariate data often arise in biomedical studies, and analysis of such data that ignores subjects with incomplete information may lead to inefficient and possibly biased estimates. A great deal of attention has been paid to handling a single missing covariate or a monotone pattern of missing data when the missingness mechanism is missing at random.(More)
Over/underdispersed count data arise in many biostatistical practices in which a number of different treatment groups are compared in an experiment. In the analysis of several treatment groups of such count data, a very common statistical inference problem is to test whether these data come from the same population. The usual practice for testing(More)
This paper focuses on the development and study of the confidence interval procedures for mean difference between two treatments in the analysis of over-dispersed count data in order to measure the efficacy of the experimental treatment over the standard treatment in clinical trials. In this study, two simple methods are proposed. One is based on a sandwich(More)
A popular model to analyse over/under-dispersed proportions is to assume the extended beta-binomial model with dispersion (intraclass correlation) parameter phi and then to estimate this parameter by maximum likelihood. However, it is well known that maximum likelihood estimate (MLE) may be biased when the sample size n or the total Fisher information is(More)
Inference on the difference between two binomial proportions in the paired binomial setting is often an important problem in many biomedical investigations. Tang et al. (2010, Statistics in Medicine) discussed six methods to construct confidence intervals (henceforth, we abbreviate it as CI) for the difference between two proportions in paired binomial(More)
The intraclass correlation in binary outcome data sampled from clusters is an important and versatile measure in many biological and biomedical investigations. Properties of the different estimators of the intraclass correlation based on the parametric, semi-parametric, and nonparametric approaches have been studied extensively, mainly in terms of bias and(More)