Kris R Payer

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We used a suspended microchannel resonator (SMR) combined with picoliter-scale microfluidic control to measure buoyant mass and determine the 'instantaneous' growth rates of individual cells. The SMR measures mass with femtogram precision, allowing rapid determination of the growth rate in a fraction of a complete cell cycle. We found that for individual(More)
Using suspended nanochannel resonators (SNRs), we demonstrate measurements of mass in solution with a resolution of 27 ag in a 1 kHz bandwidth, which represents a 100-fold improvement over existing suspended microchannel resonators and, to our knowledge, is the most precise mass measurement in liquid today. The SNR consists of a cantilever that is 50 microm(More)
Physical characterization of nanoparticles is required for a wide range of applications. Nanomechanical resonators can quantify the mass of individual particles with detection limits down to a single atom in vacuum. However, applications are limited because performance is severely degraded in solution. Suspended micro- and nanochannel resonators have opened(More)
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. ABSTRACT Nanomechanical resonators can quantify individual particles down to a single atom; however the applications are limited due to their degraded performance in solution. Suspended micro-and nanochannel resonators can achieve vacuum(More)
brief communications nature methods | ADVANCE ONLINE PUBLICATION | including approaches that average across populations as well as those that monitor individual cells; and (iv) a cell's size includes both volume and mass, which can change at different rates. Although both mass and volume are important parameters, mass is more fundamentally related to cell(More)
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