Kris Holmes

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The core protein of the hepatitis B virus, HBcAg, assembles into highly immunogenic virus-like particles (HBc VLPs) when expressed in a variety of heterologous systems. Specifically, the major insertion region (MIR) on the HBcAg protein allows the insertion of foreign sequences, which are then exposed on the tips of surface spike structures on the outside(More)
Macromolecular complexes are responsible for many key biological processes. However, in most cases details of the assembly/disassembly of such complexes are unknown at the molecular level, as the low abundance and transient nature of assembly intermediates make analysis challenging. The assembly of virus capsids is an example of such a process. The(More)
Interview of Charles Bigelow by Yue Wang, conducted in 2012. Y: In this interview we are very lucky to have Charles Bigelow with us. Professor Bigelow is a type historian , educator, and designer. With his design partner , Kris Holmes, he created the Lucida family of fonts used in the human-computer interfaces of Apple Macintosh OS X, Microsoft Windows,(More)
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