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We investigated changes in bone marrow blood flow and histology with aging in rabbits. Bone marrow blood flow was measured by the hydrogen washout method, which was performed in the proximal tibia of Japanese white rabbits, 3-42 months of age. Bone marrow blood flow was found to decrease with age. Histological observations of the proximal tibia identified a(More)
In order to determine if the functional changes in the GABAergic system in the trigeminal spinal subnucleus caudalis (Vc) are involved in the mechanisms underlying extraterritorial neuropathic pain in the orofacial region following inferior alveolar nerve transection (IANX), mechanical noxious behavior, phosphorylated extracellular signal-regulated kinase(More)
Orofacial cold hyperalgesia is known to cause severe persistent pain in the face following trigeminal nerve injury or inflammation, and transient receptor potential (TRP) vanilloid 1 (TRPV1) and TRP ankylin 1 (TRPA1) are thought to be involved in cold hyperalgesia. However, how these two receptors are involved in cold hyperalgesia is not fully understood.(More)
Pronounced ultrastructural changes in vessels and mast cells were observed in duodenal lamina propria of Wistar rats 1 year after single whole-body γ-irradiation in a dose of 7.5 Gy. Inhibition of adrenocortical function with methopyrone reduced structural damage and improved animal survival.
Electron microscopy showed that whole-body γ-irradiation in sublethal doses led to the appearance of injuries in pinealocytes, glial cells, and vessels of the pineal gland in rats. Limitation of the nonspecific effect of γ-irradiation via inhibition of adrenocortical function with metopirone in physiological doses reduced the radiation-induced(More)
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