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AIMS The purpose of this study was to characterize the internalization mechanism of human IgG into the epithelial cells of human small intestine, employing human intestinal epithelial cell line Caco-2 as an in vitro model system. MAIN METHODS Real-time PCR analysis and uptake studies of fluorescein isothiocyanate-labeled IgG (FITC-IgG) from human serum(More)
We developed murine CYP3A knockout ko chimeric mice with humanized liver expressing human P450S similar to those in humans and whose livers and small intestines do not express murine CYP3A this: approach may overcome effects of residual mouse metabolic enzymes like Cyp3a in conventional chimeric mice with humanized liver, such as PXB-mice [urokinase(More)
Chimeric mice with humanized livers (PXB mice) are used to investigate the metabolism and pharmacokinetics of drugs in humans. However, residual murine enzymatic activities derived from the liver and the presence of mouse small intestinal metabolism can hamper the prediction of human drug metabolism. Recently murine Cytochrome P450 3a gene knockout chimeric(More)
In this paper, we characterize the uptake mechanism of fluorescein isothiocyanate-labeled human immunoglobulin G (FITC-hIgG) in opossum kidney (OK) epithelial cells, which have been shown to express megalin and cubilin. Confocal immunofluorescence microscopy showed the punctate expression of the neonatal Fc receptor FcRn in the cytoplasm, but not on the(More)
The aim of this study was to reveal the expression and function of P-glycoprotein and multidrug resistance-associated proteins (MRP), members of the ATP-binding cassette (ABC) superfamily of drug transporters, in cultured human Y79 retinoblastoma cells. ABC transporter mRNA expression was evaluated by conventional reverse transcription-polymerase chain(More)
BACKGROUND Recent randomized controlled trials indicated that exercise training for elderly significantly increased their physical fitness. However, very few studies have examined changes in physical activity after exercise training. The purpose of this study was to investigate whether six-month exercise training for older adults can increase and maintain(More)
In this paper, we propose an interference power constraint method using measurement-based spectrum database for high efficient spectrum sharing. The spectrum database is constructed from measurement radio environment information measured by secondary users (SUs) with mobility, and stores radio environment maps (REMs). This paper focuses on a database-aided(More)
Spectrum sharing with cognitive radio (CR) has attracted attention to solve the shortage of spectrum resources. In a spectrum sharing environment, secondary users (SUs) can utilize spectrum bands which are licensed to primary users (PUs) under interference constraint at PUs. In order to gain the spectrum sharing efficient by setting suitable communication(More)
This paper proposes a parameter estimation method of primary user using geographical spectrum database consisting of measurement results gathered by secondary nodes. Compared to Model-based database such as FCC's database, the proposed method may enable higher accuracy spectrum sharing between secondary and primary users. Through the measurement experiment,(More)