Koushan Sineh Sepehr

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Behçet’s disease is a chronic relapsing multi-organ inflammatory disorder characterized as a triad of oral and genital ulcers, uveitis. Characteristic manifestations of Behçet’s disease are joints, skin, central nervous system and gastrointestinal tract involvement. Behçet’s disease has a complicated genetic etiology. However, epidemiological studies(More)
Background Reduction/alkylation is one of the leading strategies for the development of antibody drug conjugates (ADCs). Precise control of the reduction process would not only yield a defined number of free thiols per antibody but also result in development of more homogenous conjugates. Methods In the present study, we investigated the effect of various(More)
BACKGROUND Targeting CD20 antigen on B-lymphocytes provides good opportunity for management of the target cells in patients with B-cell malignancies. By the advent of hybridoma technology, monoclonal antibodies applications exert extensive changes in medical fields such as diagnosis, treatment and purification. OBJECTIVE The prim aim of this study was to(More)
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