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Action potential-dependent regulation of gene expression: temporal specificity in ca2+, cAMP-responsive element binding proteins, and mitogen-activated protein kinase signaling.

• R. Douglas Fields, F Eshete, Beth Stevens, Kouichi Itoh
• The Journal of neuroscience : the official…
• 1997

Specific patterns of neural impulses regulate genes controlling nervous system development and plasticity, but it is not known how intracellular signaling cascades and transcriptional activation… (More)

L1-mediated branching is regulated by two ezrin-radixin-moesin (ERM)-binding sites, the RSLE region and a novel juxtamembrane ERM-binding region.

• Ling Cheng, Kouichi Itoh, Vance P. Lemmon
• The Journal of neuroscience : the official…
• 2005

We investigated how the neural cell adhesion molecule L1 mediates neurite outgrowth through L1-L1 homophilic interactions. Wild-type L1 and L1 with mutations in the cytoplasmic domain (CD) were… (More)

Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation.

• Fumiaki Okahara, Kouichi Itoh, Akira Nakagawara, Makoto Murakami, Yasunori Kanaho, Tomohiko Maehama
• Molecular biology of the cell
• 2006

The tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) regulates diverse cellular functions by dephosphorylating the lipid second messenger, phosphatidylinositol… (More)

The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons.

• Atsushi Suzuki, Chihiro Arikawa, +7 authors Yasunori Kanaho
• FEBS letters
• 2010

The small GTPase ADP-ribosylation factor 6 (ARF6) plays crucial roles in a wide variety of cell functions. To better understand the molecular mechanisms of ARF6-mediated signaling and cellular… (More)

Possible involvement of protein kinases and Smad2 signaling pathways on osteoclast differentiation enhanced by activin A.

• Yosuke Murase, Nobuo Okahashi, +6 authors Tatsuji Nishihara
• Journal of cellular physiology
• 2001

Bone tissues reportedly contain considerable amounts of activin A and follistatin, an activin A-binding protein. In the present study, we found that follistatin strongly inhibited osteoclast… (More)

Involvement of the tumor necrosis factor (TNF)/TNF receptor system in leukemic cell apoptosis induced by histone deacetylase inhibitor depsipeptide (FK228).

• Krittaya Sutheesophon, Noriko Nishimura, +6 authors Yusuke Furukawa
• Journal of cellular physiology
• 2005

Inhibition of histone deacetylase (HDAC) is a novel strategy for the treatment of leukemias via restoration of aberrantly silenced genes. In this study, we conducted a detailed analysis of… (More)

Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway

• Yasuhiro Ishihara, Kouichi Itoh, Atsuhiko Ishida, Takeshi Yamazaki
• The Journal of Steroid Biochemistry and Molecular…
• 2015

Growing evidence shows that steroid hormones, especially 17β-estradiol (E2), protect neuronal cells by attenuating excess activation of microglia. However, the use of E2 in the clinic is… (More)

Prenatal ionizing radiation-induced apoptosis of the developing murine brain with special references to the expression of some proteins.

• Mizuki Kitamura, Kouichi Itoh, +4 authors Hiroshi Itoh
• The Kobe journal of medical sciences
• 2001

Apoptosis induced by ionizing irradiation of the developing mouse brain was investigated by using histology, analysis of DNA fragmentation on agarose gel and electron microscopy. A TUNEL-labeled… (More)

ST2 gene induced by type 2 helper T cell (Th2) and proinflammatory cytokine stimuli may modulate lung injury and fibrosis.

• Syunji Tajima, Masashi Bando, +7 authors Fumitake Gejyo
• Experimental lung research
• 2007

The authors have investigated gene expression of ST2 in the lung tissue of a bleomycin (BLM)-induced lung fibrosis model in vivo and in a human lung fibroblast cell line, WI38, and a human type II… (More)

Induction of L1 mRNA in PC12 cells by NGF is modulated by cell-cell contact and does not require the high-affinity NGF receptor.

• Kouichi Itoh, Robert Brackenbury, Richard A. Akeson
• The Journal of neuroscience : the official…
• 1995

We examined the effects of nerve growth factor (NGF) and cell-cell contact on expression of the neural cell adhesion molecule L1 in PC12 cells. After 7 d exposure to NGF, but not after exposure to… (More)

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