• Publications
  • Influence
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered theExpand
  • 2,927
  • 44
  • PDF
CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs
ABSTRACT Circular RNAs (circRNAs) are widely expressed in animal cells, but their biogenesis and functions are poorly understood. CircRNAs have been shown to act as sponges for miRNAs and may alsoExpand
  • 399
  • 31
  • PDF
miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors.
Expression of BRCA1 is commonly decreased in sporadic breast tumors, and this correlates with poor prognosis of breast cancer patients. Here we show that BRCA1 transcripts are selectively enriched inExpand
  • 380
  • 25
  • PDF
Posttranscriptional regulation of cancer traits by HuR
Cancer‐related gene expression programs are strongly influenced by posttranscriptional mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous HuR‐regulated mRNAs encodeExpand
  • 317
  • 25
Phosphorylation of HuR by Chk2 regulates SIRT1 expression.
The RNA binding protein HuR regulates the stability of many target mRNAs. Here, we report that HuR associated with the 3' untranslated region of the mRNA encoding the longevity and stress-responseExpand
  • 494
  • 24
LincRNA-p21 suppresses target mRNA translation.
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation.Expand
  • 719
  • 21
Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination.
Although mammalian long non-coding (lnc)RNAs are best known for modulating transcription, their post-transcriptional influence on mRNA splicing, stability and translation is emerging. Here we reportExpand
  • 292
  • 20
Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1
ABSTRACT HuR influences gene expression programs and hence cellular phenotypes by binding to hundreds of coding and noncoding linear RNAs. However, whether HuR binds to circular RNAs (circRNAs) andExpand
  • 304
  • 17
MKP-1 mRNA Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90
ABSTRACT The mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1) plays a major role in dephosphorylating and thereby inactivating the MAP kinases extracellular signal-regulated kinase (ERK),Expand
  • 208
  • 12
Evidence for miR‐181 involvement in neuroinflammatory responses of astrocytes
Inflammation is a common component of acute injuries of the central nervous system (CNS) such as ischemia, and degenerative disorders such as Alzheimer's disease. Glial cells play important roles inExpand
  • 174
  • 12
...
1
2
3
4
5
...