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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs
TLDR
A new web tool, CircInteractome (circRNA interactome), is presented, freely accessible at http://circinteractome.nia.nih.gov, for mapping RBP- and miRNA-binding sites on human circRNAs. Expand
miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors.
TLDR
It is suggested that miR-182-mediated downregulation of BRCA1 impedes DNA repair and may impact breast cancer therapy. Expand
Posttranscriptional regulation of cancer traits by HuR
TLDR
It is proposed that HuR exerts a tumorigenic function by enabling these cancer phenotypes, and the collections of HuR target mRNAs that encode proteins responsible for implementing five major cancer traits are reviewed. Expand
Phosphorylation of HuR by Chk2 regulates SIRT1 expression.
TLDR
The findings demonstrate that HuR regulates SIRT1 expression, underscore functional links between the two stress-response proteins, and implicate Chk2 in these processes. Expand
LincRNA-p21 suppresses target mRNA translation.
TLDR
It is proposed that HuR controls translation of a subset of target mRNAs by influencing lincRNA-p21 levels, which in turn derepressed JunB and β-catenin translation and increased the levels of these proteins. Expand
Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination.
TLDR
A post-translational function for the lncRNA HOTAIR is reported as an inducer of ubiquitin-mediated proteolysis, causing rapid decay of targets Ataxin-1 and Snurportin- 1, and preventing premature senescence. Expand
Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1
TLDR
It is proposed that the extensive binding of CircPABPN1 to HuR prevents HuR binding to P ABPN1 mRNA and lowers PABPN1 translation, providing the first example of competition between a circRNA and its cognate mRNA for an RBP that affects translation. Expand
microRNA Expression Patterns Reveal Differential Expression of Target Genes with Age
TLDR
It is demonstrated that changes in miRNA expression occur with human aging and suggest that miRNAs and their predicted targets have the potential to be diagnostic indicators of age or age-related diseases. Expand
miR-130 Suppresses Adipogenesis by Inhibiting Peroxisome Proliferator-Activated Receptor γ Expression
TLDR
The findings reveal that miR-130 reduces adipogenesis by repressing PPARγ biosynthesis and suggest that perturbations in this regulation is linked to human obesity. Expand
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