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Expression of Hypoxia-Inducible Factor-1&agr;, Histone Deacetylase 1, and Metastasis-Associated Protein 1 in Pancreatic Carcinoma: Correlation With Poor Prognosis With Possible Regulation
TLDR
The results suggest that Hif-1&agr; expression may be regulated through HDAC1/MTA1, which is associated with a poor prognosis for pancreatic carcinoma and indicates that HIF-1 &agR; and HDAC 1/M TA1 are a promising therapeutic target in pancreatic cancer treatment. Expand
Rapid-growing solitary necrotic nodule of the liver.
TLDR
The case of a rapid-growing solitary necrotic nodule of the liver occurring in a patient with chronic renal failure on hemodialysis is discussed, and permanent histology of the entire lesion is possibly the only accurate method of diagnosis. Expand
Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging
TLDR
It is found that CD9/CD81 double knockout mice with a COPD-like phenotype progressively developed a syndrome resembling human aging, including cataracts, hair loss, and atrophy of various organs, including thymus, muscle, and testis, resulting in shorter survival than wild-type (WT) mice. Expand
Type I interferons induce autophagy in certain human cancer cell lines
TLDR
A novel function of type I IFN is demonstrated as an inducer of autophagy in multiple cell lines, as indicated by an increase of autophile markers MAP1LC3-II, ATG12–ATG5 complexes, and a decrease of SQSTM1 expression. Expand
Impact of sarcopenia in patients with advanced non–small cell lung cancer treated with PD-1 inhibitors: A preliminary retrospective study
TLDR
Sarcopenia at baseline as determined using computed tomography is a significant predictor of worse outcome in patients with advanced NSCLC receiving PD-1 blockade, and screening for sarcopenia may help identify patients more likely to achieve a long-term response in routine clinical practice. Expand
Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis
TLDR
It is revealed that coexpression of intracellular adhesion molecule (ICAM)-1 on SCLC cells is essential to facilitate and accelerate the trastuzumab-mediated ADCC, and stepwise treatment with trastudumab and bevacizumab is promising for the treatment of chemoresistant SclC. Expand
CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis.
TLDR
Electrophysiological and biochemical analyses demonstrated that the exocytosis of DCVs was upregulated in the chromaffin cells and neurons of these mice, and edited CAPS1 bound preferentially to the activated form of syntaxin-1A, a component of theExocytotic fusion complex. Expand
Role of thymidine phosphorylase and orotate phosphoribosyltransferase mRNA expression and its ratio to dihydropyrimidine dehydrogenase in the prognosis and clinicopathological features of patients
TLDR
The TP/DPD ratio might be useful as a prognostic factor in patients with pancreatic cancer and evaluated the association between the expression of these enzymes and clinicopathological features and prognosis in patients in this study. Expand
Potent antitumor effects of combination therapy with IFNs and monocytes in mouse models of established human ovarian and melanoma tumors
TLDR
Results indicate that monocytes and both IFN-α2a and IFn-γ may be required to mediate profound antitumor effect against human ovarian and melanoma tumors in mouse models. Expand
Apoptosis-inducing factor (AIF) is targeted in IFN-α2a-induced Bid-mediated apoptosis through Bak activation in ovarian cancer cells.
TLDR
It is demonstrated that tBid induced by IFN-α2a activates mitochondrial Bak to trigger the loss of mitochondrial membrane integrity, consequently causing release of apoptosis-inducing factor (AIF) in ovarian cancer cells, OVCAR3. Expand
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