Kosuke Tomita

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Enzymatic degradations of 5 different polyhydroxyalkanoates (PHA) were investigated at 37°C in the aqueous solutions (pH 7.4) containing different microbial enzymes of 16 lipases and 5 PHA depolymerases. The substrate specificities of microbial PHA depolymerases on hydrolysis of polyhydroxyalkanoates were distinguished from those of microbial lipases.
A thermophilic bacterium, identified as a neighboring species to Geobacillus thermocatenulatus, having a growth optimum at 55 °C and, capable of degrading nylon 12, was isolated from soil by enrichment culture technique at 60 °C. At this temperature, the strain grew on 5 g nylon 12 l−1 with a decrease in its molecular weight from 41 000 to 11 000 over 20 d.(More)
A novel method of dipeptide synthesis is described that can be carried out in aqueous solution and does not require complicated protecting and deprotecting procedures. An analgesic neuropeptide named kyotorphin, H-Tyr-Arg-OH, was synthesized from unprotected tyrosine and arginine in a new enzymatic reaction catalyzed by immobilized tyrosyl-tRNA synthetase(More)
AIM To retrospectively evaluate the feasibility and safety of repeated transarterial chemoembolization (TACE) three or more times using miriplatin-lipiodol (M-LPD) suspension (repeated M-LPD TACE) for hepatocellular carcinoma (HCC). PATIENTS AND METHODS Sixteen patients who underwent repeated M-LPD TACE were examined. Total dose of miriplatin, lipiodol(More)
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