Kosuke Hashimoto

Publications34
h-index11
Citations700
Highly Influential Citations26
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Phosphorylation in protein-protein binding: effect on stability and function.
Posttranslational modifications offer a dynamic way to regulate protein activity, subcellular localization, and stability. Here we estimate the effect of phosphorylation on protein binding and… Expand
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Mechanisms of protein oligomerization, the critical role of insertions and deletions in maintaining different oligomeric states
The main principles of protein-protein recognition are elucidated by the studies of homooligomers which in turn mediate and regulate gene expression, activity of enzymes, ion channels, receptors, and… Expand
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Cancer Missense Mutations Alter Binding Properties of Proteins and Their Interaction Networks
Many studies have shown that missense mutations might play an important role in carcinogenesis. However, the extent to which cancer mutations might affect biomolecular interactions remains unclear.… Expand
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Caught in self-interaction: evolutionary and functional mechanisms of protein homooligomerization.
Many soluble and membrane proteins form homooligomeric complexes in a cell which are responsible for the diversity and specificity of many pathways, may mediate and regulate gene expression, activity… Expand
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CD4+ T-cell Immunity in the Peripheral Blood Correlates with Response to Anti-PD-1 Therapy
Predictive biomarkers of patient responses to immune checkpoint therapy could help identify patients whose tumors are most amenable to treatment. High numbers of circulating CD62lowCD4+ T cells… Expand
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Single-cell transcriptomics reveals expansion of cytotoxic CD4 T-cells in supercentenarians
Supercentenarians, people who have reached 110 years of age, are a great model of healthy aging. Their characteristics of delayed onset of age-related diseases and compression of morbidity imply that… Expand
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Functional states of homooligomers: insights from the evolution of glycosyltransferases.
Glycosylation is an important aspect of epigenetic regulation. Glycosyltransferase is a key enzyme in the biosynthesis of glycans, which glycosylates more than half of all proteins in eukaryotes and… Expand
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Evolutionary, physicochemical, and functional mechanisms of protein homooligomerization.
Protein homooligomers afford several important benefits for the cell; they mediate and regulate gene expression, activity of many enzymes, ion channels, receptors, and cell-cell adhesion processes.… Expand
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Oncogenic potential is related to activating effect of cancer single and double somatic mutations in receptor tyrosine kinases
Aberrant activation of receptor tyrosine kinases (RTKs) is a common feature of many cancer cells. It was previously suggested that the mechanisms of kinase activation in cancer might be linked to… Expand
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Improved efficacy of ramucirumab plus docetaxel after nivolumab failure in previously treated non‐small cell lung cancer patients
It is unclear whether the chemotherapy response improves after exposure to immunotherapy. Antiangiogenic agents have been shown to stimulate the immune system and cause synergistic effects that… Expand
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