Kosuke Hashimoto

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Phosphorylation in protein-protein binding: effect on stability and function.

Hafumi Nishi, Kosuke Hashimoto, Anna R. Panchenko
Structure
2011

Posttranslational modifications offer a dynamic way to regulate protein activity, subcellular localization, and stability. Here we estimate the effect of phosphorylation on protein binding and… (More)

Cancer Missense Mutations Alter Binding Properties of Proteins and Their Interaction Networks

Hafumi Nishi, Manoj Tyagi, +5 authors Anna R. Panchenko
PloS one
2013

Many studies have shown that missense mutations might play an important role in carcinogenesis. However, the extent to which cancer mutations might affect biomolecular interactions remains unclear.… (More)

Mechanisms of protein oligomerization, the critical role of insertions and deletions in maintaining different oligomeric states.

Kosuke Hashimoto, Anna R. Panchenko
Proceedings of the National Academy of Sciences…
2010

The main principles of protein-protein recognition are elucidated by the studies of homooligomers which in turn mediate and regulate gene expression, activity of enzymes, ion channels, receptors, and… (More)

Functional states of homooligomers: insights from the evolution of glycosyltransferases.

Kosuke Hashimoto, Thomas Madej, Stephen H. Bryant, Anna R. Panchenko
Journal of molecular biology
2010

Glycosylation is an important aspect of epigenetic regulation. Glycosyltransferase is a key enzyme in the biosynthesis of glycans, which glycosylates more than half of all proteins in eukaryotes and… (More)

Mutations that reduce its specific DNA binding inhibit high NaCl-induced nuclear localization of the osmoprotective transcription factor NFAT5.

Yuichiro Izumi, Jinxi Li, Courtney L Villers, Kosuke Hashimoto, Maurice B. Burg, Joan D. Ferraris
American journal of physiology. Cell physiology
2012

The transcription factor nuclear factor of activated T cell 5 (NFAT5) is activated by the stress of hypertonicity (e.g., high NaCl). Increased expression of NFAT5 target genes causes accumulation of… (More)

Expansion of signal transduction networks.

Bernd Binder, Oliver Ebenhöh, Kosuke Hashimoto, Reinhart Heinrich
Systems biology
2006

Signal transduction networks of different cell types show a large variety in their structural design. In this paper, basic structural properties of signal transduction networks are investigated. For… (More)

Deficiency of multidrug resistance 2 contributes to cell transformation through oxidative stress

Ali Tebbi, Florence Levillayer, +11 authors Yu -Ming Wei
Carcinogenesis
2016

Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which… (More)

Evolutionary, physicochemical, and functional mechanisms of protein homooligomerization.

Hafumi Nishi, Kosuke Hashimoto, Thomas Madej, Anna R. Panchenko
Progress in molecular biology and translational…
2013

Protein homooligomers afford several important benefits for the cell; they mediate and regulate gene expression, activity of many enzymes, ion channels, receptors, and cell-cell adhesion processes.… (More)

Expanding Large Scale Signal Transduction Networks

In recent years, much experimental effort has revealed many details of signaling pathways [2]. Using these accumulated data, large signal transduction networks have been constructed [3,4]. In… (More)

Oncogenic potential is related to activating effect of cancer single and double somatic mutations in receptor tyrosine kinases.

Kosuke Hashimoto, Igor B. Rogozin, Anna R. Panchenko
Human mutation
2012

Aberrant activation of receptor tyrosine kinases (RTKs) is a common feature of many cancer cells. It was previously suggested that the mechanisms of kinase activation in cancer might be linked to… (More)

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