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- Publications
- Influence
Phosphorylation in protein-protein binding: effect on stability and function.
- Hafumi Nishi, Kosuke Hashimoto, A. Panchenko
- Biology, Medicine
- Structure
- 7 December 2011
Posttranslational modifications offer a dynamic way to regulate protein activity, subcellular localization, and stability. Here we estimate the effect of phosphorylation on protein binding and… Expand
Mechanisms of protein oligomerization, the critical role of insertions and deletions in maintaining different oligomeric states
- Kosuke Hashimoto, A. Panchenko
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 3 November 2010
The main principles of protein-protein recognition are elucidated by the studies of homooligomers which in turn mediate and regulate gene expression, activity of enzymes, ion channels, receptors, and… Expand
Cancer Missense Mutations Alter Binding Properties of Proteins and Their Interaction Networks
- Hafumi Nishi, Manoj Tyagi, +5 authors A. Panchenko
- Medicine, Biology
- PloS one
- 14 June 2013
Many studies have shown that missense mutations might play an important role in carcinogenesis. However, the extent to which cancer mutations might affect biomolecular interactions remains unclear.… Expand
Caught in self-interaction: evolutionary and functional mechanisms of protein homooligomerization.
- Kosuke Hashimoto, Hafumi Nishi, S. Bryant, A. Panchenko
- Biology, Medicine
- Physical biology
- 13 May 2011
Many soluble and membrane proteins form homooligomeric complexes in a cell which are responsible for the diversity and specificity of many pathways, may mediate and regulate gene expression, activity… Expand
CD4+ T-cell Immunity in the Peripheral Blood Correlates with Response to Anti-PD-1 Therapy
- H. Kagamu, S. Kitano, +12 authors K. Kobayashi
- Medicine
- Cancer Immunology Research
- 23 December 2019
Predictive biomarkers of patient responses to immune checkpoint therapy could help identify patients whose tumors are most amenable to treatment. High numbers of circulating CD62lowCD4+ T cells… Expand
Single-cell transcriptomics reveals expansion of cytotoxic CD4 T-cells in supercentenarians
- Kosuke Hashimoto, Tsukasa Kouno, +17 authors Piero Carninci
- Biology
- 20 May 2019
Supercentenarians, people who have reached 110 years of age, are a great model of healthy aging. Their characteristics of delayed onset of age-related diseases and compression of morbidity imply that… Expand
Functional states of homooligomers: insights from the evolution of glycosyltransferases.
- Kosuke Hashimoto, T. Madej, S. Bryant, A. Panchenko
- Biology, Medicine
- Journal of molecular biology
- 28 May 2010
Glycosylation is an important aspect of epigenetic regulation. Glycosyltransferase is a key enzyme in the biosynthesis of glycans, which glycosylates more than half of all proteins in eukaryotes and… Expand
Evolutionary, physicochemical, and functional mechanisms of protein homooligomerization.
- Hafumi Nishi, Kosuke Hashimoto, T. Madej, A. Panchenko
- Biology, Medicine
- Progress in molecular biology and translational…
- 2013
Protein homooligomers afford several important benefits for the cell; they mediate and regulate gene expression, activity of many enzymes, ion channels, receptors, and cell-cell adhesion processes.… Expand
Oncogenic potential is related to activating effect of cancer single and double somatic mutations in receptor tyrosine kinases
- Kosuke Hashimoto, I. Rogozin, A. Panchenko
- Biology, Medicine
- Human mutation
- 1 November 2012
Aberrant activation of receptor tyrosine kinases (RTKs) is a common feature of many cancer cells. It was previously suggested that the mechanisms of kinase activation in cancer might be linked to… Expand
Improved efficacy of ramucirumab plus docetaxel after nivolumab failure in previously treated non‐small cell lung cancer patients
It is unclear whether the chemotherapy response improves after exposure to immunotherapy. Antiangiogenic agents have been shown to stimulate the immune system and cause synergistic effects that… Expand