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Changes in hemostatic parameters in hepatic veno-occlusive disease following bone marrow transplantation
Hepatic veno-occlusive disease (VOD) is a major complication after bone marrow transplantation (BMT). Its prediction, diagnosis and treatment remain unclear. Examination was made of changes in… Expand
Activation of Akt is associated with poor prognosis and chemotherapeutic resistance in pediatric B-precursor acute lymphoblastic leukemia.
BACKGROUND Activation of the phosphoinositide 3-kinase (PI3K)/Akt pathway, a pro-survival pathway, plays important roles in tumor cell growth. However, the role of Akt in the pathogenesis of… Expand
Successful Chemotherapy for Congenital Malignant Gliomas: A Report of Two Cases
We describe the cases of 2 patients with a congenital malignant glioma that responded to chemotherapy. In the first case, a 2-month-old boy had a conjugate deviation to the right side and nystagmus.… Expand
Longitudinal study on selenium content in human milk particularly during early lactation compared to that in infant formulas and cow's milk in Japan.
- Y. Tamari, K. Chayama, H. Tsuji
- Chemistry, Medicine
- Journal of trace elements in medicine and biology…
- 1 March 1995
239 samples of human breast milk were collected from 36 healthy Japanese women. Selenium content of the samples was determined mainly by highly sensitive fluorometric analysis with… Expand
Relationship between oral mucositis and high-dose methotrexate therapy in pediatric acute lymphoblastic leukemia.
- T. Maiguma, Y. Hayashi, +8 authors D. Teshima
- International journal of clinical pharmacology…
- 1 November 2008
OBJECTIVE Oral mucositis is a major toxicity in the high-dose methotrexate (HD-MTX) treatment for children with acute lymphoblastic leukemia (ALL). The first aim of this study was to evaluate the… Expand
Unrelated donor bone marrow transplantation for 100 pediatric patients: a single institute's experience
Summary:In all, 100 unrelated donor bone marrow transplantations (UD-BMT) were performed in our institute between October 1993 and January 2003. Of 93 evaluable patients, 73 patients had… Expand
CD34+ progenitor cell transplantation from two HLA-mismatched healthy fathers to two infants with severe aplastic anemia.
Pluripotent stem cells of hematopoiesis are included among CD34+ cells in the blood and bone marrow. After granulocyte-colony stimulating factor (G-CSF) mobilization, 1-2% of the mononuclear cells in… Expand
[A phase III study of the efficacy and safety of meropenem in patients with febrile neutropenia].
- K. Imajo, Y. Ueda, +18 authors K. Tamura
- Medicine, Biology
- The Japanese journal of antibiotics
- 1 August 2012
Efficacy, safety and pharmacokinetics of meropenem (MEPM) were assessed when 1 g (40 mg/kg for some of the pediatric patients) t.i.d. was administered every 8hours to 101 adult and 6 pediatric… Expand
ABL kinase mutation and relapse in 4 pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia cases
- Michinori Aoe, A. Shimada, +12 authors T. Morishima
- International Journal of Hematology
- 21 March 2014
The tyrosine kinase inhibitor (TKI) imatinib mesylate (IM) revolutionized the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-ALL), which had showed poor prognosis… Expand
Persistent clonal chromosomal abnormalities in a chronic myeloid leukemia patient.
- M. Muraoka, K. Washio, +7 authors A. Shimada
- Pediatrics international : official journal of…
Clonal cytogenetic abnormalities (CCA) in Philadelphia chromosome (Ph)-negative cells have been reported in a small population of adult chronic myelogenous leukemia (CML) patients during the clinical… Expand